I've used clinda lotion, however, not by itself. I hate to be negative, but I really don't think clinda lotion on its own will really help your acne, unless it's very very mild. My derm told me that studies have shown that while on an oral antibiotic, a topical antibiotic (like clinda) increases effectiveness. Not sure how good of results you'll get by using just the clinda alone though... If you ONLY want to use a topical, I'd say your best bet is Retin-A, Differin, or Tazorac-- NOT clinda. good luck!