I tried the nitro, and didn't have much success but then I went to a different doctor and got what was called diltiazem (sp?). It really worked, along with taking warm baths, drinking alot of water and watching my diet. When I went back for my check up the doc will do a botox injection if the fissure was not healed. When she checked me she said wow, the fissure is just about healed from the medication, but gave me the botox injection anyway. OUCH! :eek: But even without it, I had very good results from the diltiazem. Maybe ask your doc about it! Good luck!