Discussions that mention diovan

High & Low Blood Pressure board


Four years I was diagnosed with HBP (I was 28 then) - said it was hereditary. I was placed on a low does of Verapamil and after 2 weeks on it had an AWFUL reaction and ended up in the ER -- such horrid chest pain and tightness - thought I was having an asthma attack - though at that time I had not been diagnosed with asthma yet. -- Not an attack - just an adverse reaction to the Verapamil.

I was taken off that and placed on 25mg of Toprol and then increased to 50 mg 2 years later. Also, about the time I was taken off Verapamil my Dr. diagnosed me with asthma though my pulmonary test came back fine???

So I take Toprol 50 MG and FLovent 2 puffs times 2 times per day and Ventolin as needed. Well in October my breathing became BAD - had not had ANY problems with in since being diagnosed?? But out of nowhere.

So takes me off Toprol (in 4 days??? the withdrawl was HORRID) - tries me on Diovan -- HORRID COUGH and upper chest tightness, then on a Diuretic - again horrid horrid chest tightness (no cough) - but leg cramping.

Go back and puts me back on 25 mg Toprol and 80 mg Diovan (which I had to stop AGAIN because of the cough and chest tightness) - and also tells me to start taking Prilosec for GERD and poossible Hiatal Hernia.....

Well long story short, breathing bad again and I go back Friday to try yet ANOTHER NEW HBP med -- what is left for me to try?????

Thank you......
Hi Vanessa, :)

I know you are awaiting your doctors' appointment anxiously. As discussed previously in another post, beta blockers should be avoided completely in people with asthma unless otherwise indicated.

The one antihypertensive medication you might not have tried is an ACE inhibitor. Some people get pretty bad cough as a side effect. Otherwise, all things considered it is an excellent medication for a number of reasons. It is used in treating several medical conditions and has been proven very effective in blood pressure control. It is often combined with a diuretic for a greater reduction in blood pressure.
Some people with an elevated blood pressure find that a single drug, a diuretic, is enough to maintain their target blood pressure. The drug therapy needed to bring the blood pressure to goal depends on the overall health of patient & CVD risk factors, the type of hypertension and its severity. The response to drug therapy varies from patient to patient.
I too experienced extreme reaction to two drugs from the ARB class of antihypertensives, Diovan and Micardis. I cannot tolerate them at all. I wonder if you could be experiencing side effects from your asthma drug interaction with the other meds. I was on Advair for a time with no relief in symptoms and stopped taking it altogether. The fewer meds we take, the better.
Good luck with your appointment! I hope you feel better soon and your breathing improves.

flowergirl
Thank you so much for your input. I too tried Diovan and had a HORRID reaction to it - an AWFUL cough and the most horrid upper chest tightness. So I am scared to try another ACE Inhibitor....

I wonder if he (my Dr.) - will let me go off all my meds just for a while to purify my body and then add one at a time to better determine what is going on. I have lost 16 pounds and radically modified my diet to help with my health.

I am probably just wishful thinking! My B/P is pretty high so he probably won't go for this!!

I would really love to stop the Flovent because it does not seem to be working, the last 5 nights I have woken up every hour unable to breath - it never ever used to be this bad at night - now I am afraid to sleep. I am afraid to stop the Flovent because I am afraid I will have an asthma attack.

Thank you for all your posts - you have an incredible wealth of knowledge. I have been reading all your posts - and you have inspired me to order some books and start educating myself on my conditions.

Thanks again!
Thanks Beth :) :)

I was put on Toprol 4 years for HBP - started at 25 mg and then increased to 50mg 1 & 1/2 years ago. He had originally started me on Verapamil (a CCB) - but I had an 'adverse reaction' to that after being on it for 2 weeks - severe upper chest tightness that landed me in the ER - so that is when I was switched to Toprol.

I do understand from research that Toprol can be hard on the stomach - and I begin having some 'heartburn, etc.' about 4 or so months ago. The significant breathing problems started in late October 2007. I did some research and found Toprol can cause breathing problems so brought this up to my Dr. right away.

He sent me to a pulmonologist for a second PFT in 4 years - and all was normal -- BUT the pulmonologist increased my asthma meds anyway and told me OFF TOPROL now..... Told me I did not need to wean????

So back to my regular Dr. and even though he said my PFT looked normal and like I do not have asthma??? He took me off Toprol over only a 4 day period of time (worse withdrawl I have ever had - horrific) - then tried on Diovan 80 mg (could not tolerate, cough and chest tightness), then on to Diazide HCT (made me feel awful). When I went back to try something ELSE - he put me back on a low does of Toprol after being completely off it for a couple of weeks because he felt that if it was the Toprol causing the breathing problems I would be breathing better after two weeks (I wasn't really breathing too much better). So he put me back on 25 mg and had me try it with 80 mg Diovan -- COULD NOT. So is leaving me on 25 mg Toprol for now until he can decide what to do next????:confused::confused:

At the same visit (all this in early Dec) he started me on the Prilosec OTC.

I have since heard that Beta Blockers can take up to (2) months to completely get out of your system. What are your feelings on this?

Also, what medication should I try next for the HBP??? I am so scared:(:(
[QUOTE=Vanessa74;3390287]Thanks Beth :) :)...
Vanessa, you are so very welcome!

[QUOTE]I was put on Toprol 4 years for HBP - started at 25 mg and then increased to 50mg 1 & 1/2 years ago. He had originally started me on Verapamil (a CCB) - but I had an 'adverse reaction' to that after being on it for 2 weeks - severe upper chest tightness that landed me in the ER - so that is when I was switched to Toprol.

Well, I'd definitely stay away from amlodipine/norvasc, which is a ccb, unless you id exactly what's causing the problem...famnd may be able to give you more info on that.

[QUOTE]....I did some research and found Toprol can cause breathing problems so brought this up to my Dr. right away.

Good! We need to do a better job of educating our doctors.

[QUOTE]...He sent me to a pulmonologist for a second PFT in 4 years - and all was normal -- BUT the pulmonologist increased my asthma meds anyway and told me OFF TOPROL now..... Told me I did not need to wean????

I've been seeing a pulmonolgist, too, since he is my sleep medicine specialist. He told me I didn't have asthma and said my lungs were fine. Duh??? Then why couldn't I breath??? I went back and forth between my primary and my specialist only to find the answers on my own. As far as weaning off of a beta blocker, from what I've read, it's dangerous not to do so....one reason is that not all heart problems are identified by doctors and if there is an underlying heart problem, it could be fatal. I think you've learned about the other reasons why one should wean...and personally, I think the dosage, whether small or large, is irrelevant.

[QUOTE]...So back to my regular Dr. and even though he said my PFT looked normal and like I do not have asthma??? He took me off Toprol over only a 4 day period of time (worse withdrawl I have ever had - horrific) - then tried on Diovan 80 mg (could not tolerate, cough and chest tightness), then on to Diazide HCT (made me feel awful)....

Both diovan (valsartan) and hct list breathing problems as side effects, by the way.

[QUOTE]... When I went back to try something ELSE - he put me back on a low does of Toprol after being completely off it for a couple of weeks because he felt that if it was the Toprol causing the breathing problems I would be breathing better after two weeks (I wasn't really breathing too much better)....

It takes at least a week for toprol to lower pressures...I doubt very much that 4 days after disco'ing toprol you'd be breathing better. From personal experience with a variety of side effects, after discoing a drug, some side effects would start to diminish within hours...but some took longer. When I disco'd my ccb, due to sleep problems, I slept all the night the first few nights (probably because I was so sleep deprived)...but it took over 6 weeks before I started sleeping though the night EVERY night. Another example I can offer is a friend, a nurse actually, who developed a terrible rash on her face. It took several months for her and her doctor to figure out the rash was due to the diuretic, hydrochlorothaizde (hct)....and it took several MONTHS after discontinuing the medication before her rash went away...now breathing problems and rashes are not the same thing...but I think you get my point.

[QUOTE]...I have since heard that Beta Blockers can take up to (2) months to completely get out of your system. What are your feelings on this?

I strongly agree!!!! I discontinued my beta blocker, atenolol, abruptly due to suicidal tendencies and falls...I lost 10 pounds the first week simply because I could move again, but it took a number of weeks for all of me (mind, body, and spirit) to return to normal. Oh, and I do believe I experienced rebound hypertension (hypertension that was higher than it was before I took medication) when I discontinued my bb. Although I do not know how toprol is broken down in the body, I do know that a number of factors impact the way we process/eliminate drugs--water composition, fat composition, muscle composition, liver function, kidney function, age, etc...and everyone is different!! So it may take some people longer to "get back to normal" than it would take other people. And just for your info, they used to test meds on young white men which means the reactions/experiences in women will quite likely be very different due to differences in fat and muscle composition. Doctors aren't always aware of this and overmedicate women (and older people) as a result.

[QUOTE]Also, what medication should I try next for the HBP??? I am so scared:(:(

I don't know what med to suggest...I suppose it would depend on what kind of reactions you had to your previous medications. I know your experiences were terrible but it may help others to know exactly what kinds of reactions you've had...that way people who have had experienced similar bad reactions could offer ideas as to what has worked for them.

Have any of your doctors ever given you a reason for your hypertension at such a young age (28)? I would think that there may be an underlying condition that may be complicating things a bit, but I don't know.

It's understandable to be scared...but that fear is protecting you! You're becoming actively involved in your care which in the long run will keep you safer and healthier than if you believed everything you were told. The answers are out there and I think you'll find them...just keep your old detective hat on and keep an open mind and question EVERYTHING and EVERY SOURCE because no one is right all the time.

Take care, Vanessa. Do stay in touch.

Bethsheba
Hi Beth and Fam,

Thank you for the information.

Not sure what medication to go to next - feel sort of out of options and scared. I was diagnosed at 28 with HBP, I am now 34. I have a 'family history' for HBP so that is what my Dr. is attributing it to. Tested my thyroid and it was fine?? What other reasons could there be behind the High B/P???? Any other tests that I should ask for to rule out other things?

Though to my credit - I do not smoke or drink, I watch my diet strictly and I am not overweight. NOW - I need to add exercise!!!!

Beth,

When your pulmonologist said you didn't have asthma but you still could not breath - what answers did you find? Did any asthma meds help you? What were your medication side effects?

With the CCB (Verapamil) -- I had EXTREME upper chest tightness, felt like an elephant was sitting on my chest 24/7 -- only took the Verapamil for (2) weeks and this side effect took almost (2) weeks of being off the medication to go away.

With the Diovan -- I was on it about (7) days when I began to get a tickle in my throat and a cough - then it started to feel like someone was grabbing the muscles in my upper chest and pulling them tighter and tighter.

With the Diazide HCT - I would get similar chest tightness to the Verapamil - but it would come and go sometimes lasting for up to an hour at a time - then I would get bad headaches on it.

The Toprol was GREAT GREAT GREAT for 4 year - NO PROBLEMS except making me tired so I would just take it before I went to bed - it was GREAT. Then got switched to the generic without my knowledge (10/07) - and HORRIBLE BREATHING PROBLEMS - chest tightness, inability to get a breath all the way down into my lungs, the feeling that all of sudden I just could not breath, feeling like someone had a belt around my chest and was PULLING and PULLING... I switched back to the regular Toprol 20 days later - but TOO LATE, the side effects persist....

On the PPI Prilosec OTC -- the same chest tightness and pulling that I had on the Diovan -- I wonder if it is because they are both 'inhibitor' drugs?????

I also take Flovent HFA (2) puffs twice a day and Ventolin as needed for the asthma -- not sure if I have it or not but with the horrid breathing problems scared to give it up :(:(:(