Discussions that mention diovan

High & Low Blood Pressure board


Hi, this is my first time to post here. I was diagnosed with HBP 5 years ago when I was 31, otherwise am healthy, in shape etc. The doctor prescribed Lisinopril 40mg & a diuretic. Every year when I went back to the doctor BP was fine & I really didn't experience any side effects. This year I moved & had to go to a new doctor in July to get my prescription. He told there me was this great new drug out called Tekturna & it was much better than Lisinopril. Said Lisinopril relaxed the blood vessels after they were already constricted, whereas Tekturna worked much earlier in the chemical process to keep vessels from constricting in the first place. He didn't refill the Lisinopril & instead gave me a month's worth of Tekturna samples.
What a disaster! BP went up instead of down, plus I felt terrible while taking this, i.e. severe indigestion, aching muscles etc. It also messed up my heartrate, alternating between very fast & very slow. By day 8 I'd had enough, went back to Dr.. BP was 180/120. He added a drug called Azor, Buspar for anxiety (I'd never had anxiety till I went to see this guy!) & told me to come back in a couple days & he would add a Beta Blocker. Enough was enough, I went to another Dr., told him the situation, he put me back on the Lisinopril, said I should've been left on it. Also told me that his office had not given out any Tekturna samples, nor prescribed it yet, were waiting for more feedback.
While going thru this, I've done a lot of research on this drug, talked to many different people. With drugs such as Lisinopril, Diovan, Micardis etc, most of the issues generally concern the side effects & whether they are tolerable, not the fact of whether they work. With Tekturna there seems to be a great debate on if it even works & there's quite few terrible experiences like mine. Have also noticed the longer this drug is out the more it's prescribed as an add-on therapy vs stand alone treatment.
Anyhow, I just wanted to tell of my experience with Tekturna. This drug is so new it's hard to find much info on it. I also appreciate this health board, it's been very informative. This was the 1st time I'd ever went thru anything like this & it was pretty scary, so it's good to have a forum like this where people can share their experiences.
If anyone should try this drug I hope their very careful, check their BP & pulse constantly. It's been 18 days since I stopped taking Tekturna & I'm still not completely normal again.
Thanks for the post, Shane. It's the first one I've come across that shows Tekturna doesn't work for EVERYONE (I was starting to feel like a freak!) I was diagnosed with HBP in 1992 and have been on a variety of meds since then, although with little great success. I had lived with relatively high readings for ages (160's/100's) until about five years ago when I dropped to 130's/80's. I attribute this to starting low carb eating and starting fish oil supplements.

Recently, I had an episode of stroke-like syptoms that lasted several days before I finally called the doctor on a Saturday and was told to go to the ER to be checked out. Everything tested fine. When I saw my physician for a follow up, he said he felt I was finally experiencing effects of having high blood pressure for so many years, and my readings were currently high again as in years past. I told him the only thing I had changed in my routine was that I had stopped taking the oil supplements a few months earlier. Due to surgery for an enlarged prostate several years ago, I had been bleeding into my bladder over the last couple years whenever I exerted myself. I'd learned that vitamin E, particularly when obtained via fish oil, had a significant blood thinning effect. I decided to stop the oil pills as an experiment, and I stopped bleeding no matter how active I was. I suggested to the doctor that I believed my increased blood pressure was too coincidental with this situation, but I was too concerned with the prospect of bleeding again to go back on the oil. He said we have to start working harder to find something that works. He prescribed HCTZ in addition to my Diovan 360 and said to monitor my BP at home and come back in a month at the end of July.

Not much changed overall. After the middle of the month, when my readings were starting to go into the 170's/100's, I decided to start back on the oil but at two thirds the previous dosage and see what happened. The systolic dropped back down into the high 140's, low 150's, diastolic dropped to high 90's, low 100's. At the beginning of August he took me off the HCTZ and gave me almost two months samples of Tekturna 300 to take at bedtime with the Diovan.

The morning before starting Tekturna, I measured 147/98. The morning after the first Tekturna pill I measured 182/110; forty minutes later I was 180/115. That evening after work I was 188/112, and when I hit 191/122 twenty minutes later, I called the doctor and asked what he thought was going on. He said to add the HCTZ back in and monitor the BP and let him know how things went. I wanted off the Tekturna, but he said to stay on it.

My morning readings were all over the map, ranging from mid-130's/mid-90's to high-160's/mid-110's. My evening readings dropped to what is considered normal, but only because I drink two, sometimes three martinis a night. But after starting the Tekturna, I began not feeling well, particularly in the mornings. Couldn't explain it to him well, just a feeling of being ill. I started getting heartburn that would last all day (I never had heartburn before). After a few weeks of that, I called for an appointment and saw his associate who was in disagreement with the use of Tekturna this early in its public distribution. He put me on Coreg, but said to keep taking everything else and talk to my regular doctor in a few days.

Again, nothing much changed other than the fact that I was now taking four pills for blood pressure and not seeing results. About a week later I let my doctor know I was running low on Tekturna and asked if I could go off it. He told me no, he would put in for an approval from my health carrier for the Rx. I knew this would be a third tier drug, and I wouldn't care if I were seeing results and felt well. I started trying again to find cases similar to mine, but was coming up with nothing. The only drug interaction I could find that applied to me was that I was taking Lipitor, and that can cause too much Tekturna to be in the bloodstream. I was also surprised to see he started me on the 300mg pills when the standard routine is to start a patient on 150mg.

Several days ago, my mail order pharmacy left a message that they couldn't process one of my prescriptions. I went online and found the doctor had sent an Rx to them for 90 days of the Tekturna 300. I tried without luck to find out why they couldn't process it, but bottom line, I was happy. I could find no details on how to wean oneself off the drug and decided to just cut the 13 pills I had left in half and take them until they were gone. I know the standard warning is to not stop any medication unless discussed with a doctor, but in this case I felt he was not paying enough attention to my concerns.

After about a week on the half-pills now, I don't have that sick feeling anymore; I feel "normal" again. My morning readings are coming down steadily, and the evening readings look good, particularly after alcohol intake. In a few days, I will be out of Tekturna and will have to see what happens. I have an appointment in the beginning of October and will have to reveal my course of action and the results. If my BP looks the way it did before the Tekturna, I will refuse to go back on it if he suggests that. What I think he should do is put me at the next dosage level of the Coreg and see what that does (the starting dose is 20mg and they titrate you up in steps up to the max dose of 80mg if necessary).

As I've read elsewhere, not everyone's physiology is the same and doctors can't expect all drug therapy to work the same on everyone, even if the majority says it does. I used to suffer from anxiety disorder for years and the medical community couldn't find a reason for it and couldn't treat it successfully with any of the standard medications. My research into the diseases of the nervous system led me to the effects of vitamin B on the nerves. I read that alcohol depletes the body of B, and so it made sense to me that I might have a deficiency, but I tested ok in this respect. Regardless, after reaching a point where I felt the disorder was affecting my heartbeat and breathing, I took it on myself to do the only thing in my power, which was to start taking a vitamin B supplement heavy in B12 and B6. Within days, DAYS mind you, the symptoms I had suffered with for years disappeared. My vision, which had also been affected, started improving. As long as I kept taking the super-B complex, I was fine. If I discontinued it, my symptoms would start returning within days. When I discussed this with my doctor at my next visit, he told me I was either experiencing a placebo effect, or the medical world hasn't learned enough about vitamin's effect on different people. This was five years ago. I have recently read neurologist's reports on the astonishing effects of vitamin B therapy in their patients suffering from anxiety disorder; these were therapies started right around the time I started it. Don't be afraid to believe you're different from other people and that maybe what works for someone else, maybe EVERYONE else, won't work for you. Don't lose sight of the possibility that maybe something you're taking is having a negative effect on you. I don't advocate trying to be your own doctor, but I do highly recommmend you read as much as you can and take ownership of your health. Be able to discuss your condition with your doctors in a responsible way to reach your health goals.
I haven't taken the HCT version, but I take Tekturna 150mg daily and it's doing a great job on my essential hypertension. It's the first ARB I've been able to tolerate. I tried Benicar HCT, and it made me ill - nausea, dizziness, and heart rate changes). I tried Micardis and had a similar response. I suffered for a year on Diovan HCT and had a lot of dizziness. I tried Atacand and again, experiences dizziness. So it could be that Tekturna just doesn't work for you.
Mike,

Great recap of your experience and I'm glad I found this site today. For the last 4 years I've been in hell dealing with the drugs the Dr's put me on. I sent to ER for reactions to Diovan, and Norvasc. Whatever they did to my body, they also made me allergic to aspirin which I was taking daily on my own until the Dr.'s got a hold of me. I was on Coreg and Tekturna together for a while and almost lost my job. I could no longer think clearly, fatigued all the time and making really stupid mistakes that I had never made before. I stopped the Coreg on my own. I've been battling with the weight gain and other side effects that have come with all these medications. Now that I read your post about Tekturna I plan to wean myself off of that as well. Over three years I am eating healthy and now work out three times a week. However, I still have weight issues and fatigue. I suspect that as soon as I am of the Tekturna, I will see my weight drop. Because of my heart healthy diet and taking fish oil and garlic, vitamin B and D, I will not have any issues with my blood pressure. I monitor it daily and had no issues coming off the Coreg.

I found your comments about Lipitor and Tekturna interesting. I too take Lipitor and have since it first came out and suspect that is the culprit of my overall problem. Once off the Tekturna I will focus on getting off the Lipitor. I can't wait until the day I am drug free!

My Dr.'s show little to no concern, which why should they, it's my life, my body and now I'm in chage...they just hellped me get there.