Discussions that mention effexor

High & Low Blood Pressure board


Hi flowergirl,

Thanks for your post and help :). It seems that CCBs are the best drug class for me, both my father and my uncle are on Norvasc :D. They feel good too, thank god for that.

No I stopped Zebeta after after 6 days of using it because it lowered my heart rate to 48 and even 40 :(. With Norvasc my heart rate is 76 to 84, which makes me feel normal. Anyway, my dr told me to take 5mg at morning and another 5mg at night. I did that but I think it didn't work as I take the 10mg once daily, afte 2 hours of drinking my coffee to make sure it doens't effect the medication much :). Anyway, at our next meeting I will tell him about that and see what he would say. He's a great dr :).

I have another problem that is not relevant to Norvasc, few days ago the dr up my Effexor XR dose from 75mg to 150mg and my heart rate has increased (was 106 yesterday). I can't exercise much while having that heart rate, but the wierd thing is that it goes down to 80 after I drink my daily coffee. What do you think?
Thanks again for help,
Michael
Hi Michael,

A couple of things you should know.

Effexor will cause an increase in heart rate. It is one of its side effects. Another is an increase in blood pressure.
Don't be surprised if your blood pressure becomes elevated, in spite of you doing everything you can to keep it down. There have been sustained increases in blood pressure in some patients on this drug. They were modest ones, averaging 10-15mmHg.
The incidence of sustained hypertension for Effexor xr is dose-dependent. If this becomes a problem, a dose reduction or discontinuation of the drug is recommended.
Avoid alcohol - that used with too much of this drug can kill. If you find yourself with free time on your hands, look up the Serotonin Syndrome this drug causes in some people. Tachycardia is just one of its many symptoms.
I don't know how caffeine brings the pulse rate down - when/if I do, I'll post it here. :) Your blood pressure is very good!

flowergirl
Hi flowergirl,

When I started Effexor XR I started with 75mg for a month, in the first few days I have had faster heart rate then it was fine. Anyway, in the 5th week (I'm in my 6th now) my dr put me on 150mg. I started to get higher heart rate again, sometimes it's 78, 84, 88, 105 and 120, I will go to my dr after 10 days if my heart rate didn't go down. But there has been no increase in my blood pressure at all, thank Jesus for that :).

The current biggest problem I'm having is that I can't concentrate and I'm tired all the day, I have done every blood work and some nuclear scans and I'm very healthy. It's a Depression and Anxiety and finally I admitted that to myself. Effexor XR supposed to give me out of depression and makes me feel good, but after about 37 days I feel the same plus I'm tired and dizzy most of the time from it.

I have been told by some patient, that I have found online, that all the tiredness and dizziness would disappear after 2 month. It takes 2 month for the medication to start working, they say and I hope so.
Please if you know more about this let me know :D. I'm very grateful to you for makeing me switch to Norvasc, I can't thank you enough dear.
One more thing, I don't drink Alcohol. I'm trying to live healthy as much as I can but it seems that I'm not doing a good job.
Thanks again for help,
Michael
Hi,

Effexor XR 150mg made my heart rate 110+ in 10 days :(, dr put me back on 2.5mg Zebeta and reduced my Norvasc to 5mg. Heart rate, after 4 hours of Zebeta, is 71 and blood pressure is 121/72. I will see what would happen in a week because I have reduced effexor xr to 75 again.
Michael
Hi Bethsheba,

Thanks for your help, actually I also take Xanax before I sleep. But I was on Diltiazem for more than 2 years and it never caused any sleep problems. Also Norvasc is better than Diltiazem for me :D, it's the bes medication I have tried so far. As for the Effexor XR I will wean myself off it, anti-depressants are very bad drugs :(. I will take Omega 3 + Amino Acids + Vitamin C + B Complex + Magnesium supplements, I hope this will help with my depression. Also I will take xanax for few months, but I think it's addictive, isn't it?
Thanks for help and happy new year
Michael
Hi Michael, :)

[QUOTE]Effexor XR 150mg made my heart rate 110+ in 10 days :(, dr put me back on 2.5mg Zebeta and reduced my Norvasc to 5mg. Heart rate, after 4 hours of Zebeta, is 71 and blood pressure is 121/72. I will see what would happen in a week because I have reduced effexor xr to 75 again.

I tried to tell you the 10mg dose of CCB is too high. You get used to it eventually, but it causes disturbances in the electrical system of the heart (at least in some people!!!) which can't be that good in the long run....never mind the other side effects I will not go into. For this reason, I am glad to hear you are back to 5mg a day. The Zebeta will help to keep your heart rate down yet it is a small enough dose not to affect your exercise tolerance greatly. Give yourself time and try not to become too frustrated if you don't get perfect blood pressure readings rightaway. I know you can't do much about the Effexor...it is supposed to be one of the milder drugs of its type but watch out for that one! I hope things work out for you...look at me. As soon as I start believing I have just the right combination of medicine in the right dosage, something needs to be changed. The effectiveness of our medication is determined by a number of variable factors. That is why frequent adjustments in dosage or changes in medication are sometimes necessary.

Good luck! :)
flowergirl
Hi flowergirl,

I hope you had a new Christmas :). Please can you explain what do you mean by "You get used to it eventually, but it causes disturbances in the electrical system of the heart". I didn't have any problems with 10mg of Norvasc, but I'm back to 5 mg because I have to lower my heart rate using Zebeta. Effexor is a very bad drug and I will not take any antidepressant again, I will take natural supplements like omega 3, magnesium, vitamin C, B Complex and Amino Acids. Also I will go to the church more often, we get too busy and forget god :(. which is the primary reason for depression and anxiety in the modern world.

My heart rate is 71 and I'm feeling good again, but the problem is that I'm weaning off effexor and when I stop it my heart rate MIGHT drop again to 40 or 48 :(. I will see what would happen.

I want ask you something about Zebeta, I have read that it can cause Depression and in the same time it's anti-Anxiety. I feel the anti-Anxiety effect, but I'm scared that it depress me.
Thanks for help,
Michael
Hi Michael, :)

Happy New Year to you and everyone on these boards!

I did a little bit of reading about Zebeta in a couple of my drug books. Then I looked up Effexor and checked its side effects. I am so glad to hear that you will be stopping this drug!

I think you will feel much better after you discontinue Effexor. If you are young (and I know you are) you should not be on this drug. The depression, anxiety, nervousness, irritability and many other symptoms can be attributed to the use of this drug in some people. The doctors, when prescribing this drug, should carefully weigh its benefits against the risks in certain populations, especially the young and the elderly. It improves certain mood problems but creates others, sometimes very serious.

I don't think that the Bisoprolol is responsible for your symptoms, because your dose is small. Some beta blockers cause confusion, paranoia, emotional depression and nervousness. The symptoms are directly dose related. The ones most often mentioned (along with many other meds that can cause these states) are Propranolol and Metaprolol.
An interesting fact: Pharmacokinetic interactions of beta blockers (Rate of absorption, distribution, metabolism and excretion) vary according to individual agents' chemical properties. Lipid soluble beta blockers -Bisoprolol, Metoprolol and Carvedilol involve a specific enzyme when they are metabolized (CYP2D6). Some people have less of this enzyme than others. Because of its reduced concentration, there is a higher risk of drug interactions and adverse reactions in these individuals. These same people can be unaffected and symptom free when using a beta blocker that is water soluble, such as Atenolol.

By the way, when compared to other beta1 selective blockers, (Metoprolol, Atenolol and Betaxolol) Bisoprolol has been shown to have the highest beta1 selectivity. Good to know! :)

Have a good day!

flowergirl
Hi flowergirl,

:) Thanks for the great info and I'm very sorry for wasting your time. I think that Zebeta acts as anti-Anxiety too, is that for real or just I'm feeling it wrong?

I will wean myself off both Effexor and Xanax this week, I hope it will not take more than a week. I have been on both for about 6 weeks only so I think it's not very difficult.

My heart rate is 60-64 and my blood pressure is 126/74 so it's great :D. Zebeta 2.5mg + Norvasc 5mg is better than 10mg of Norvasc alone as you said. I hope my heart rate wouldn't drop further.
Thanks again for help,
Michael
I believe that you are very right flowergirl, we should learn as much as we can about our medication. I knew that SSRI like Effexor are very bad drug class, but I had to try it so I would convince myself that I have done what I could. I have also read that Amino Acids, like Tryptophan increases Serotonin levels in the brain. So I'm weaning myself off both Effexor and Xanax and started to take 2,400mg of balanced Amino Acids supplements 2 day ago. But someone made me worry about Serotonin Syndrome, that might happen while being on antidepressant and Amino Acids supplements together. Anyway, this is my third day and I'm not feeling any difference.

By the way, I drink 2 cup of coffee daily now :D and my blood pressure is great. I started to feel better, not because of the bad antidepressant that is causing many bad side effects. I'm feeling good because I started to look at my life from another aspect.

I'm very thankful for helping me flowergirl :).
Michael
I have seen my dr today and he told me that my heart rate is 70 and my blood pressure is 130/80 :). Not more Amino Acids until I'm off Effexor (after 10 days from now). What concerns me is this, I use a German Digital BP Monitor and my dr is using a mercury BP Monitor. The results are 10 points different in my Diastolic but I took a cup of coffee before I go to him.
Thanks for your great help and support dear
Michael