I've used methotrexate (which worked wonders for me) and that was discontinued after a few years and then I went to imuran. I'm now doing the Enbrel injections while taking imuran (which after awhile will be discontinued also - the imuran, that is). After only 3 injections (they're done twice a week) I am starting to feel a difference. As far as diet is concerned - I've never noticed in myself that anything triggered flare ups. The only thing that would cause mine to really flare up is over-use and bad weather approaching.