Hi Romi...my symptoms (if I can remember that far back) started out as swelling and pain in just one knee. One day I fell and it seemed like it kicked it into high gear. Over the years more joints started swelling, getting painful and eventually started to deform. I've had an athroscopy done on my knee and had to have my thumb straightened out last year because it was so deformed. I am not able to straighten out my elbows or my knees totally. I have fingers, toes, feet, knees, elbows and wrists involved. My wrists have fused by themselves so I'm not able to bend them at all. I was on methotrexate (a blessing then) for a few years then switched to Imuran. Currently doing Enbrel injections while still taking Imuran and prednisone. Eventually (hopefully) these 2 meds will be discontinued. I would love to have my knees replaced but they won't do it at my age. I'm still able to work and get around and do things but it's real painful at times. Although the Enbrel has helped a lot. I still have good days and bad days. But my bad days aren't as severe.