I am familiar with that debilitating fatigue. You should see a rheum. and get a diagnosis. If it is RA, you might want to try enbrel. I swear when I got first injection (from nurse) I felt better within A FEW HOURS! I still have some pain but it is manageable. I have lots of energy (clean my big house, babysit grandkids, etc.) I am not like my old self but pretty darn close.