I took methotrexate for a few years. It was a god-send in the beginning. Helped me tremendously. But I also continued to take prednisone and ibuprofen. I never had any side effects from it. But 2-3 years ago I started losing a lot of my hair and told my rheumy about it. Seeing that methotrexate is a chemo drug I could understand why I would think it would do this. So he took me off it and I started Imuran shortly after. I didn't find it to be as effective. Then I started having female problems and then wondered if maybe it was my hormones that caused my hair to fall out. Maybe a combo of both. I just don't know. I am now doing the Enbrel injections. Which have been working well.