I have taken methotrexate and lost my hair and my liver count went sky high so they took me off it, I have taken sulphasalazine and leflunomide all with severe side effects, and my rheumatologist is seeing me in November to discuss enbrel, or remecaid, but dont know if I will get it due to strict pct guidelines here in Britain. I have heard people say that they tried all the other drugs, with no joy, and then went on to enbrel and felt absolutely brilliant again. If you do get on it and the results are good, keep us all informed. The best thing for my arthritis was methotrexate, but it didnt do the rest of me any good!! Good luck hope you feel good soon.