Discussions that mention enbrel

Arthritis board


Hi Ronnie,
im afarid i dont actually have any experience of these drugs but know other people who have used them. Some people say they get the choice between the enbrel and humira first, from those i've spoken to choose humira as it is made from human protein as oppose to enbrel which is made from mice protein. As i've not actually researched this myself i dont know what the drugs are actually made from, only by what others have said. None of them have reported anything awful and feel much better in being able to move freely and less pain. I think it is down to individual though to see what works for them. Hope others will beable to give you some of their experiences. Keep us posted as to how appointment goes.
Best wishes
wenXXX.
The TNF's are like this:

Enbrel = Fusion protein from human derived TNF-a receptor (no mouse). Binds to free TNF-a

Humira = Recombinant human monoclonal antibody - Binds to free TNF-a

Remicade = Chimeric monoclonal antibody with murine (mouse) and human components - Binds to free TNF-a


So, these are the 3 that bind to TNF-a. Enbrel is the only one that is not an antibody. The molecules basically float around like little sponges soaking up TNF. Theoretically the lease "invasive" as it is fully human AND not an antibody. Remicade is the highest risk as it is an antibody AND it has mouse parts in it. So, my advice is to start with the Enbrel and see how it does. I've been on it almost 3 years and is still working. The others can always be tried later if Enbrel doesn't fly.


Now, the real nuclear ones are these:

Amevive = Fusion protein of LFA-3 and human IgGL Fc region (immune globulin) - Eliminates T-cells by binding to natural killer (NK) cells

Raptiva = Humanized monoclonal antibody - Blocks T-cell activation in skin (only for psoriasis)

These actually go directly after immune system cells and modulate their number and/or activity. Pretty risky and should only be used after other bios have failed.

Good luck with whatever you decide.
Hi Ronnie,

I have psoriatic arthritis too and have been on enbrel for several years now and love it. I haven't noticed any side effects and have virtually no pain. My psoriasis has pretty much cleared up with an flare up once in a while but no big deal. I don't understand all the medical jargen being used here, just wanted to give you my 2 cents! :)

Good luck!
GS
Personally im on the prednisone, plaquenil, (was on methotrexate but had bad side effects) was on enbrel it worked some for a while but then the flares started more frequent & worse so dr switched me to humira every other week it helps 1st week of the shot but by 2nd week im in pain again dr said if it continues he will up it to once a week

Good Luck I hope they find the right combo for ya

Thats basically what this is trial & error finding the right combo to treat each person

Have faith & stick in there :)
I have been on enbrel now about 5 months. I was scared at first to inject myself was it was no big deal at all. for the relief I get its worth it. the fatigue lifted straight away after the first injection. I still get a lot of pain but compared to how I was its a miracle. I can play with my Grandchildren now and live a much more normal life. I inject in the stomach and it doesnt hurt at all.
bjm0903...so sorry to hear about your breast cancer. Hope it all turns out well for you.

I was on Enbrel for 8 years and it worked very well for me. I stopped it because it caused me to gain a lot of weight. How long were you on Enbrel and was your breast cancer caused just by Enbrel or do you have other risk factors like family history, hormone therapy, etc.
I was on enbrel for 2 years. I do not have a family history and have been genetically tested which was negative. I was pre-menopausal and was on birth control pills. I am not over weight, exercise everyday and do not smoke. I was on methotrexate too so I guess this could have contributed but I think Enbrel is to blame. (it is an anti tumor necrosis factor so it blocks your bodied ability to fight tumors).