Discussions that mention estradiol

Acne board


Joe,
Caffiene also raises your IGF-1 levels, but only you can determine how sensitive you are to caffiene. I rarely get it in my diet unless I'm eating a bit of dark chocoloate, coffee or tea, otherwise...no primary sources of caffiene in my diet.

Also, I don't know how much of this you will be able to understand, but this is just to show you the facts based around my "theory":

The androgenic profile of women with non-insulin-dependent diabetes mellitus. - 2004
"The serum levels of FSH, LH, estradiol, total testosterone, androstenedione and DHEAS were significantly higher in diabetic [Type II] patients than in the control group (p < 0.05). In contrast, the levels of SHBG were lower in diabetic [Type II] patients (p < 0.05)."

[url]http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15493567[/url]



What may be the markers of the male equivalent of polycystic ovary syndrome? - 2004
"It was possible to form two subgroups. The first one showed similar hormonal changes as women with PCOS, the other had either no anomalies in steroid spectrum or just only lower level of sexual hormones binding globulin (SHBG)."

[url]http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15209536[/url]



Glucose and insulin components of the metabolic syndrome are associated with hyperandrogenism in postmenopausal women: the atherosclerosis risk in communities study. - 2004
"Higher FAI was associated with the hyperinsulinemia and hyperglycemia components of the metabolic syndrome"

[url]http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15353414[/url]



***Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men.- 2004
"Low total testosterone and SHBG levels independently predict development of the metabolic syndrome and diabetes in middle-aged men."

[url]http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15111517[/url]



Prostate cancer: another aspect of the insulin-resistance syndrome? - 2004
"Men adopting a low-fat diet and daily exercise reduced their levels of serum insulin and IGF-1, while increasing their levels of IGFBP-1 and sex hormone-binding globulin (SHBG)."

[url]http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12458975[/url]



Dietary composition in restoring reproductive and metabolic physiology in overweight women with polycystic ovary syndrome. - 2003
“On the LP [(55% carbohydrate and 15% protein)] diet, high density lipoprotein cholesterol decreased 10% during energy restriction (P = 0.008), and the free androgen index increased 44% in weight maintenance stages (P = 0.027).”

[url]http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12574218[/url]



Effect of rosiglitazone on spontaneous and clomiphene citrate-induced ovulation in women with polycystic ovary syndrome. - 2003
"Rosiglitazone [Avandia] therapy improves insulin sensitivity and decreases hyperandrogenemia primarily through increases in SHBG."

[url]http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12620440[/url]



Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations - 2002
"Higher fat intake, in particular saturated fat, was associated with lower levels of IGFBP-3. We conclude that higher energy, protein, and milk intakes were associated with higher levels of IGF-I. These associations raise the possibility that diet could affect cancer risk through influencing IGF-I level."

[url]http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12223429[/url]



Reducing bioavailable sex hormones through a comprehensive change in diet: the diet and androgens (DIANA) randomized trial. – 2001 “In the intervention group, sex hormone-binding globulin increased significantly (from 36.0 to 45.1 nmol/liter) compared with the control group (25 versus 4%,; P < 0.0001) and serum testosterone decreased (from 0.41 to 0.33 ng/ml; -20 versus -7% in control group; P = 0.0038).”

[url]http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11205485[/url]



Postprandial changes in sex hormones after meals of different composition. - 2001
“There was a significant decrease in testosterone and free androgen index after both tofu and lean meat meals [in male test subjects]”

[url]http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11319710[/url]



The effects of metformin and diet on plasma testosterone and leptin levels in obese men. - 2001
"We conclude that metformin treatment combined with a hypocaloric diet leads to reduced FT levels in obese nondiabetic men and to reduced TT levels in obese men with type 2 diabetes. Increased SHBG levels may account for the decrease in FT levels in the former group."

[url]http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11707532[/url]



Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome. - 2000
"Metformin treatment of women with PCOS results in a decline of insulin as well as total and bioavailable T, leading to significant improvement of clinical manifestations of hyperandrogenism"

[url]http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10856473[/url]



Association of dietary factors and selected plasma variables with sex hormone-binding globulin in rural Chinese women. - 1996
"the strongest predictors of SHBG concentrations were the dietary intake of rice (beta = 0.42, P < 0.01), fish (beta = 0.34, P < 0.05), millet (beta = -0.27, P < 0.01), and wheat (beta = -0.34, P < 0.01). "

In other words, Rice RAISED SHBG, while Wheat LOWERED SHBG! =0
[url]http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8604665[/url]



KEY:
IGF-1 - Insulin-like Growth Factor. Multiple jobs including reducing the amount of Insulin in the blood stream. Considered the "super insulin' and responds whenever Estradiol or DHT (dihydrotestosterone) require it's assistance in stimulating cell or even tumor growth.

IGFBP-1,2,3 - Insulin Like Growth Factor Binding Proteins - bind IGF-1, IGF-2

FAI or FT - Free Androgen Index, also known as Free Testosterone. Converts into DHT, which is responsible for sebum gland growth, sebum secretion, etc.

SHBG - Sex Hormone Binding Globulin, has a higher affinity for binding Free Testosterone, rendering it inactive. Multiple studies have shown that SHBG has an inverse relationship with Insulin.

Total Testosterone (T) - All 5 forms of testosterone. Can show up as normal, but that doesn't mean that you aren't producing too much of one form.

Estradiol (E2) - the more active/potent, yet sometimes "bad" Estrogen form. Works wonders in birth control for some women with acne because estrogen & SHBG have a direct relationship. Raise your estrogen levels and you will raise your SHBG.

DHEA-S - dehydroepiandrosterone sulfate. This is the bound & usually inactive form of DHEA and is considered an adrenal androgen.

Androstenedione - another form of testosterone/androgen

LH - Luteinizing Hormone

FSH - Follicle Stimulating Hormone

HDL - High Density Lipoprotein, otherwise known as the "good cholesterol"

LDL - Low Density Lipoprotein, otherwise known as the "bad cholesterol"


***For males it's a bit confusing because Testosterone is your primary hormone so SHBG levels can be higher or lower and your total testosterone can be higher or lower. Yet usually Free Testosterone will be higher when your SHBG is lower (which some men prefer libido wise).

Oh and the most brilliant thing about having Insulin Resistance, Metabolic Syndrome, or Hyperandrogenisim, is that you may never know until it's too late. This is particularly true with hyperandrogenisim because you do not have to have acne, hirstuism or androgenic alopecia as your warning signs. Nope, you can have obesity, menstrual or fertility problems, rheumatoid arthritis, some other skin condition, heart disease, or cancer. That's what makes the human body so absolutely brilliant! There's not always the same predictable response to the same stimuli in....basically the same, but geneticially different individuals.