Discussions that mention estradiol

Acne board

I have said this time and time again, and frankly as much as I love you guys, i get why people leave this board. =P No one has time to constantly argue and debate with, usually the same, individuals that FAIL to realize how something as simple as food can affect our hormonal system 100%!!! Am I saying that if you follow the "right" diet for you (trial and error) you can be 100%* acne free, yes! Am I saying that diet is the only way you can be 100% acne free, no. Leo's book is lovely (but overpriced), but it doesn't cover as much knowledge as others, including myself, have acquired regarding SPECIFIC diets and how they affect our hormonal & immune response (inflammation). Oh and, there are FREE acne books out there (including a copy of his), you just have to know where to look for them ;-)

Obviously you have to understand what these abstracts are discussing, but I didn't understand all of this stuff myself 3 years ago, but I wanted it badly enough that I kept researching, even after I had tried the diet and found that it worked for me. Yet, I still didn't fully understand HOW it could work, even though it was working above my guarded expectations, but I have a much greater understanding now:

[quote]Am J Clin Nutr. 1996 Jan;63(1):22-31. Related Articles, Links

Association of dietary factors and selected plasma variables with sex hormone-binding globulin in rural Chinese women.

Gates JR, Parpia B, Campbell TC, Junshi C.

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853-4401, USA.

Sex hormone-binding globulin (SHBG) is an important regulator of plasma sex steroids as well as a sensitive indicator of insulin resistance. SHBG may be an important diagnostic measure of risk for pathologies associated with insulin resistance syndrome (IRS) such as non-insulin-dependent diabetes mellitus (NIDDM), obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. In women, SHBG is also implicated in diverse pathologies such as cancers of steroid-sensitive tissues and hirsutism. Data from an ongoing ecological study linking diet and health in rural China were analyzed to determine the relation of selected plasma variables and diet to plasma concentrations of SHBG. All data represent county mean values, pooled by age and sex, to assess the relation between biochemical and lifestyle characteristics and disease-specific mortality rates at the county level. The study sample consisted of 3250 Chinese women between the ages of 35 and 64 y living in 65 widely dispersed rural counties. Consumption patterns for 21 different food groups were derived from a food-frequency questionnaire and a 3-d dietary survey and subsequently compared. Correlation analyses of county mean values demonstrated a significant association between SHBG and insulin, testosterone, triacylglycerols, body mass index, age at menarche, and several foods. In regression analyses, after adjustments, the strongest predictors of SHBG concentrations were the dietary intake of rice (beta = 0.42, P < 0.01), fish (beta = 0.34, P < 0.05), millet (beta = -0.27, P < 0.01), and wheat (beta = -0.34, P < 0.01). When insulin, testosterone, and triacylglycerols were added to the model only triacylglycerols (beta = -0.26, P < 0.05) remained a significant independent predictor of SHBG. Additional analyses suggested that the consumption of green vegetables was modestly positively correlated with SHBG and negatively with insulin values. Consumption of rice and fish in particular appeared to favorably influence the principle plasma variables associated with a reduction in the risk for IRS pathologies.

Perhaps this will be an easier read of the above for some of you:
Cornell-China study suggests rice-based diet

[quote]Am J Clin Nutr. 1996 Dec;64(6):850-5. Related Articles, Links

Effects of dietary fat and fiber on plasma and urine androgens and estrogens in men: a controlled feeding study.

Dorgan JF, Judd JT, Longcope C, Brown C, Schatzkin A, Clevidence BA, Campbell WS, Nair PP, Franz C, Kahle L, Taylor PR.

Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892-7326, USA.

We conducted a controlled feeding study to evaluate the effects of fat and fiber consumption on plasma and urine sex hormones in men. The study had a crossover design and included 43 healthy men aged 19-56 y. Men were initially randomly assigned to either a low-fat, high-fiber or high-fat, low-fiber diet for 10 wk and after a 2-wk washout period crossed over to the other diet. The energy content of diets was varied to maintain constant body weight but averaged approximately 13.3 MJ (3170 kcal)/d on both diets. The low-fat diet provided 18.8% of energy from fat with a ratio of polyunsaturated to saturated fat (P:S) of 1.3, whereas the high-fat diet provided 41.0% of energy from fat with a P:S of 0.6. Total dietary fiber consumption from the low- and high-fat diets averaged 4.6 and 2.0 g.MJ-1.d-1, respectively. Mean plasma concentrations of total and sex-hormone-binding-globulin (SHBG)-bound testosterone were 13% and 15% higher, respectively, on the high-fat, low-fiber diet and the difference from the low-fat, high-fiber diet was significant for the SHBG-bound fraction (P = 0.04). Men's daily urinary excretion of testosterone also was 13% higher with the high-fat, low-fiber diet than with the low-fat, high-fiber diet (P = 0.01). Conversely, their urinary excretion of estradiol and estrone and their 2-hydroxy metabolites were 12-28% lower with the high-fat, low-fiber diet (P < or = 0.01). Results of this study suggest that diet may alter endogenous sex hormone metabolism in men. [url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8942407]http://www.ncbi.nlm.nih.gov/entrez/query.f...st_uids=8942407[/url]

I will say that males are more complicated than females when we look at changes in androgen production. Middle-aged males go through something similar to menopause (less estrogen more androgens) in women, known as Andropause (less androgens more estrogen/estradiol) and as such when you start looking at studies with males in their 30s or older, its' a bit conflicting. Although usually what stays the same is that the SHBG levels will increase, and usually more than the observed increases for Total Testosterone, Free Testosterone, etc.

[quote]Nutr Cancer. 1998;31(2):127-31. Related Articles, Links

Effects of diet and exercise on insulin, sex hormone-binding globulin, and prostate-specific antigen.

Tymchuk CN, Tessler SB, Aronson WJ, Barnard RJ.

Department of Physiological Science, School of Medicine, University of California, Los Angeles 90095-1527, USA.

A diet high in fat has been linked to prostate cancer, possibly through an influence on hormones. Sex hormone-binding globulin (SHBG) binds androgens and is regulated in part by insulin. Diet and exercise can modify insulin levels, potentially affecting SHBG and the biologically available levels of androgens. To determine the effects of a low-fat (< 10% of calories), high-fiber diet plus daily exercise on insulin, SHBG, prostate-specific antigen (PSA), and serum lipids, we measured the levels of these factors in the serum of 27 obese men undergoing a three-week diet-and-exercise program. Insulin decreased from 222 +/- 30 to 126 +/- 21 pmol/l (p < 0.01), and SHBG increased from 18 +/- 2 to 25 +/- 3 nmol/l (p < 0.01). Body mass index decreased from 35 +/- 1.9 to 33.4 +/- 1.8 kg/m2 (p < 0.01). PSA levels were normal and did not change significantly, although in a small subset of men (n = 3) with slightly elevated PSA levels (> 2.5 ng/ml) all showed a decrease. The three-week diet-and-exercise intervention decreased insulin and lipid levels while increasing SHBG. The increase in SHBG would result in more testosterone being bound and, therefore, less of the androgen available to act on the prostate. The decrease in insulin might also decrease mitogenic activity in the prostate. The diet-and-exercise regimen did not have a significant impact on normal PSA levels. Although modest, these changes may be protective against the development of prostate cancer.