Discussions that mention evista

Cancer: Breast board


I am considering volunteering myself for a human research for osteoporosis. One of the drugs is Evista, and another experiencial drug (unknown to me)
is in the drug class of Tomoxifin. I've never taken either of these drugs....can any of you give me the side effects ? I have no health challenges known to me now and post menopausal and have female organs.
Hey--I'm not a breast cancer survivor, but I am a cancer biology/pharmacology student, so here's my few cents:

Tamoxifen is an estrogen analogue. In breast tissue, it acts as an anti-estrogen--it binds to the estrogen receptor, preventing estrogen from binding. Since estrogen is a mitogen in ER-positive cancers, tamoxifen treatment helps kill the cells. However, in all other tissues, tamoxifen has estrogenic activity--this is why there is a (low) risk of uterine cancers associated with tamoxifen use, and it also explains some of the other side effects.

Evista (raloxifene) is another estrogen analogue that's in trials as a cancer therapy. It was originally used in therapy for osteoporosis, as estrogen helps prevent loss of bone matter. The advantage that Evista seems to have over tamoxifen is that it has no estrogenic activity in uterine tissue, so there should be no increase in the risk of uterine cancers. I don't know if there's a difference in the side effects--it might be worthwhile to find someone who's taken it for osteoporosis and see what they think.
Hey--I'm not a breast cancer survivor, but I am a cancer biology/pharmacology student, so here's my few cents:

Tamoxifen is an estrogen analogue. In breast tissue, it acts as an anti-estrogen--it binds to the estrogen receptor, preventing estrogen from binding. Since estrogen is a mitogen in ER-positive cancers, tamoxifen treatment helps kill the cells. However, in all other tissues, tamoxifen has estrogenic activity--this is why there is a (low) risk of uterine cancers associated with tamoxifen use, and it also explains some of the other side effects.

Evista (raloxifene) is another estrogen analogue that's in trials as a cancer therapy. It was originally used in therapy for osteoporosis, as estrogen helps prevent loss of bone matter. The advantage that Evista seems to have over tamoxifen is that it has no estrogenic activity in uterine tissue, so there should be no increase in the risk of uterine cancers. I don't know if there's a difference in the side effects--it might be worthwhile to find someone who's taken it for osteoporosis and see what they think.
Hey--I'm not a breast cancer survivor, but I am a cancer biology/pharmacology student, so here's my few cents:

Tamoxifen is an estrogen analogue. In breast tissue, it acts as an anti-estrogen--it binds to the estrogen receptor, preventing estrogen from binding. Since estrogen is a mitogen in ER-positive cancers, tamoxifen treatment helps kill the cells. However, in all other tissues, tamoxifen has estrogenic activity--this is why there is a (low) risk of uterine cancers associated with tamoxifen use, and it also explains some of the other side effects.

Evista (raloxifene) is another estrogen analogue that's in trials as a cancer therapy. It was originally used in therapy for osteoporosis, as estrogen helps prevent loss of bone matter. The advantage that Evista seems to have over tamoxifen is that it has no estrogenic activity in uterine tissue, so there should be no increase in the risk of uterine cancers. I don't know if there's a difference in the side effects--it might be worthwhile to find someone who's taken it for osteoporosis and see what they think.