Jbaby - I've never heard of anyone taking more than 200 mg twice a day. That is what I have been taking now for 2 1/2 years. The benefits out-weigh any problems or side effects. I take one in the morning with breakfast and one with supper. I also take an anti-flamatory, Feldene once a day, with supper also. I just feel so much better I hope I never have to go off it!!