Discussions that mention fluvastatin

High Cholesterol board


A number of factors went into our decision to list rosuvastatin as a DO NOT USE drug:

1. Rosuvastatin joins atorvastatin and fluvastatin as the statins that have not demonstrated a health benefit to the patients that use them in terms of reducing the serious cardiovascular consequences of high cholesterol such as a first or second heart attack or stroke. Lovastatin, pravastatin, and simvastatin have shown such benefits to patients in addition to their cholesterol lowering properties and this is reflected in the professional product labels and advertising for these drugs.

The only reliable, valid indicator that consumers can use that a drug has a demonstrated health benefit is if that information is contained in the drug's FDA approved product labeling. Advertising claims for drugs can not be made unless research has been submitted to and approved by the FDA that the drug will actually do what a manufacturer claims it will do.

2. Rosuvastatin causes abnormal elevations in urine protein and blood that are signals for serious kidney toxicity; other statins are not associated with this risk of kidney toxicity.

3. Rosuvastatin is the only statin that has shown life-threatening rhabdomyolysis in pre-approval clinical trials.

In summary, rosuvastatin has no proven health benefit as discussed above, it can cause potentially serious kidney toxicity that is not seen with the other statins, it is the only statin that caused rhabdomyolysis, a life-threatening adverse drug reaction, in pre-approval clinical trials, and there are already three statins on the market that are safer than rosuvastatin and have demonstrated a health benefit to patients.

What You Can Do

There is no medical reason for you to be taking rosuvastatin when there are three safer and more effective statins, in terms of reducing cardiovascular events, on the market.

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