I've been on Humira for 5 years, with pretty good results. I still had bad flares, and occasionally had to use a wheel chair, up until about a year ago. Then I started working out regularly (in spite of the pain at first). Now I've reduced or stopped all my other meds, except for the Humira. I haven't had a flare in over a year, and I've started entering 5K's. My rheumatologist told me for years that exercise would help, but I never listened (who can exercise when you can barely move)! I'm so glad I finally did it, though! My life has improved greatly. Good luck to you!