I've tried everything for severe psoriatic arthritis. I also have osteoarthritis. I tried prednisone, methotrexate, Humira, and Remicade. None of them worked. My arthritis is in my neck, spine, hips and all of my joints. My ribs hurt so bad it hurt to breathe. My SI joints really hurt to the point of hardly being able to walk. I was sick all the time because I'd catch everything with a lower resistance.
Finally my doctor tried Enbrel. With in a month the horrible fatigue was gone. My pain went from a 9 to a 5. I never get sick anymore. I used to get a cold and be in bed so sick for two and a half weeks. I'd need a doctor's visit and antibiotics, sometimes IV's. Not anymore. I'm so much better. I give myself injections 2x per week. Hope this helps someone.:)