I am 28 and new to AS--I have joint pain in my wrists and hands and some back pain. My rheum. told me I have degeneration in my SI joints and inflammation around my sternum...I have been on 15mg of mobic for 1 year (pluspain meds as needed and tylenol as needed) but am now being told to try Humira...any advise for me about this drug??? I am scared of taking the next step and the long term effects..I am getting worse I know and will start medical school in the fall--the stress will only make me worse...any suggestions for meds? Thanks so much for your time and responses. I am up for trying dietary changes, meds, etc....thanks again.