I have anxiety disorder and high blood pressure. I have been on Metoprolol (50 mg, twice a day) and Lotrel (5/10 mg) for about 6 or 7 months. Since I started taking the medications, I have lost about 20 pounds and started running again. I have been running 2-4 miles a day, about 5 days a week. I feel great, but are there any potential problems with the beta blocker and heavy cardio workouts? I don't feel tired or slow, but how should it affect my target heart rate. My heart rate goes from about 125 at the beginning of the run up to about 145 or slightly higher at the end of the run or on hills. Any thoughts?