I take 2 meds -- atenolol (beta blocker) and mavik (ACE inhibitor). Between the two the main effects I notice are a higher degree of fatigue than I used to experience, plus some water retention, evidenced by slight ankle swelling. It's hard to determine which medication causes these effects, or whether it's from the combination. Also, I've gone through menopause in the past year, so I'm sure that's affecting me too! Getting older ain't easy!