Hello, I have beenon Suboxone for about 1 1/2. I take 1, 2mg pill a day. When I started the Suboxone, I started the morning after my last pill, i.e. I probably took my last pill around 8:00 p.m. and took my first dosage of suboxone around 6:00 a.m. the next morning. As for taking hydro while you are on Suboxone, there is really no point, you won't feel the hydro. There is Naloxone in Suboxone and it blocks the effects of the hydro. In fact, even if you didn't take suboxone for a 2 days you wouldn't feel the hydro. Suboxone is a very, very good deterent! My only other advise would be this, start out the suboxone on as low of a dose as possible. I was taking anywhere from 20 to 30 hydros a day. I never had any withdrawl when starting the suboxone. I started at the lowest dosage because I don't have any insurance and it was the cheapest amount I could take. My doctor has also told me that a lot of doctors over prescribe the suboxone. I have tried numerous times to get off the suboxone and have never been successful. My doctor keeps telling me that since i am on such a low dose I should have little to no withdrawal. Well, let him go through it! Cuz the last time I tried to get off of it, I was so sick for a week I thought I would die, I went back on it! I just figure if I am on it for the rest of my life, so be it. I am happier, cleaner and have more money than I ever had in my whole life. I figure, what ain't broke, don't fix! Anyway, Suboxone has been a miracle drug for me. I am 38 years old and I can't think of time I was ever sober. Diet pills when I was a teen, heroin, cocain, methadone, pain killers, you name it I have been addicted to it. I am a totally different person now. Mentally, I am much stronger. It is hard to describe but I don't ever get depressed anymore, well not like I used too, I am not needy and miserable anymore either. I hope what i have told you helps.....