Arava has been around for about the past 7 years or so. I have been on it since Oct. 31 (along with Mobic and Plaquenil) and have gotten good results. It is less toxic than methoxatrate, although you have to have periodic blood tests to check for liver problems. So far, I have had no side effects and the pain has subsided - still have slight inflammation in a few fingers, but I am much improved since I started these medications. Dont be afraid to try it. If you type ARAVA into your browser, several sites will come up and you can research it. The more you can find out about all these medications, the better you will understand what can be helpful to you. Good luck!