[QUOTE=brianpain33;3508365]...I have read about pure opium (from which morphine) is derived or synthesized and the effects are pure pain relief with no drowsiness, but merely levels of muscle relaxation. Why is it that the drug companies have never been able to do this or do they just not want to?
This is an inaccurate picture of how opium works. Actually, pure opium will cause significant sedation. Back in the days of opium eaters and smokers the users would be nodding off throughout the whole experience. In fact, sedation was part and parcel of the desired experience.
The history of managing pain has been mostly aimed at acute pain, in which the typical effects of analgesia, sedation and anti-anxiety are desired. Fighting chronic pain is relatively recent and there has been little success in removing the sedation from narcotics. This is why my PM doc prescribed dexedrine automatically along with the opioid. The other reason she prescribed dexedrine is that it potentiates the opioid, making it even stronger against pain.
This whole field is just so complex. But, as you have posted, it sure would be nice to see a new generation of pain killing medications that would handle the pain without causing sedation, nausea, tolerance and dependence. That's the one I want.