Discussions that mention nadolol

High & Low Blood Pressure board


Lavenderfields,

Half life of any substance refers to the time it takes for 1/2 of the drug (or radioactive substance) to be destroyed, excreted or otherwise made inactive. So 9-12 hour half life of bisoprodol means that in approximately half a day more than half the drug is gone and you have slightly less than a half dose active. After 9-12 more hours, half of THAT amount is gone and on and on to vanishing amounts.
Thus, you can see that a beta blocker like propranolol, with a half-life of 2-4 hours (from memory, don't quote me) needs multiple daily dosing to remain effective all day and a drug like nadolol with a 72 hour half life take forever and a day to leave our systems (and is thus "self weaning".) Another ramification is that the VERY long half life drugs increase the chance of overdose by combining each day's dose with an appreciable amount of the last day's dose (and the day before, and the day before THAT!)

When you hear the term referring to radioactive decay...like a half like of 24,000 years for Plutonium 239, if you have a spill into the atmosphere all you have to do is wait patiently for 24,000 years and the situation will become only HALF as bad! :jester: :jester:

(I hope that explanation helped.)