Discussions that mention nadolol

High & Low Blood Pressure board

From the Astra Zeneca prescribing information:
[QUOTE]In man, absorption of an oral dose is rapid and consistent
but incomplete. Approximately 50% of an oral dose is
absorbed from the gastrointestinal tract, the remainder
being excreted unchanged in the feces. Peak blood levels
are reached between two (2) and four (4) hours after
ingestion. Unlike propranolol or metoprolol, but like
nadolol, TENORMIN undergoes little or no metabolism by
the liver, and the absorbed portion is eliminated primarily
by renal excretion. Over 85% of an intravenous dose is
excreted in urine within 24 hours compared with
approximately 50% for an oral dose.
differs from propranolol in that only a small amount
(6%-16%) is bound to proteins in the plasma. This kinetic
profile results in relatively consistent plasma drug levels
with about a fourfold interpatient variation.
The elimination half-life of oral TENORMIN is
approximately 6 to 7 hours

Thus, it is dispelled pretty quickly but some people have MUCH longer weaning times because, I think it's use over time trains the adrenals to produce more catecholemines (adrenaline and noradrenaline.) Some people can be jumpy and tachycardic for weeks afterward til the adrenals adjust to the drug's absence.