Discussions that mention norco

General Health board

i just read that drinking grapfruit juice before taking hydrocodone can increase the effectiveness. has anyone done this and if so was it effective. my norco aren't as effective anymore. thanks, jason
Wow! I have never heard of grapefruit juice "increasing" a medications effect; but I do know that it can "decrease" the effects of some medications. So check if you are on other medications, it may not be safe. As for me..........I'm on Norco and heading out to the grocery store to pick up........you guessed it! Grapefruit juice!! LOL