I am a Chronic Pain patient as well as BiPolar and PTSD, Cluster Migraines and a Seizure Disorder. I'm on Fentanyl 50mcg every 48 hrs as well as Ultram 200mg/day, and Norco for BT pain. I also take Topomax 100mg, Lamictal 200mg, Seroquel 450mg, Zoloft 50mg, and Neurontin 600 mg and Singulair 10 mg. I also use Axert for onset Migraines. So I as well am on tons of meds but have never had a problem with my pain meds affecting my BP meds.