Discussions that mention norvasc

High & Low Blood Pressure board


Since they are two different topics, I'll deal with them separately.

Central aortic pressure

It may be more important than peripheral (brachial artery) pressure to the outcomes, such as a stroke and heart disease.
While the brachial artery diastolic pressure is a good indicator of central aortic diastolic pressure, that's not the case with the systolic pressure.
Brachial artery systolic does not accurately reflect central aortic systolic pressure. This is noticable especially in patients older than 60 years who are on atenolol specifically.
The heart and brain are exposed to aortic, not the brachial, pressure. The beta blockers were associated with a smaller reduction in central aortic pressure, compared to other antihypertensives, such as ACE inhibitiors or the calcium channel blockers. Both Norvasc and Amlodipine have been shown to be more effective for lowering central aortic pressure than the atenolol.
In one recent study, the differences between brachial and aortic pressures averaged 4-5 mm/Hg. In another, the CCBs reduced central aortic pressure by 4.3 mm/Hg, which represents a 20-30% reduction of the risk of stroke. Losartan (an ARB) also outperformed the beta blocker atenolol. In my opinion, though a 5 point difference between brachial and aortic pressures might not seem like an awful lot, the potential reduction of the risk of stroke these five points translate into seems huge and disproportionate. I would say that a person at high risk of a stroke should not rely on the beta blockers exclusively for best protection.

flowergirl
[QUOTE=flowergirl2day;3200997].... Both Norvasc and Amlodipine have been shown to be more effective for lowering central aortic pressure than the atenolol....flowergirl

Just a quickie...amlodipine is the generic of norvasc.

Bsheba
[QUOTE]Just a quickie...amlodipine is the generic of norvasc.

Yes of course it is. I should have caught it, as I've been on both. I read several studies, physicians comments and subsequent analytical write-ups. It's a wonder I was able to think straight at all by the time I finished! I just missed it. Thank you for the correction.

flowergirl