i've been on the wellbutrin for almost a year now. and it works great along with the lexapro for my depression. i've taken paxil and zoloft before and neither of those worked. my doctor doesnt want me to go off my meds for a very long time because i relapsed so badly when i went off of them, and they work great, except for my anxiety. they helped my anxiety when i am in a car (i used to not be able to be in a car because i had such bad anxiety about riding in them) and now i can go pretty much anywhere with anyone and am becoming more comoftable finally with driving on interstates my self. and that is a huge deal for me and my family because it caused a major headache for everyone for a long time. but it doesnt really help my anxiety i get when i start obsessing over myself.