Discussions that mention paxil

Depression board


I've been clinically depressed for several years now. I tried several AD's with no luck, paxil, prozac, wellbutrin, celexa, zoloft, and finally effexor xr helped at the low dose of 75mg. Well about a year ago it starting to lose it's effectiveness. I saw someone and was diagnosed at the time with major depression recurrent without pyschotic features, needing a possible change in medicine and needing to rule out bipolar because it runs in my family. Well this month I went to a pdoc and he diagnosed me as bipolar II. Which I still really don't accept. Though I did have one mania episode in my life. It was 5 years ago and lasted about a year. First time it ever happened and it has never happened again. Most of the time I am depressed, sometimes severely, just existing. By this time I am up to 150mg of effexor xr and 300 of wellbutrin which I didn't see any difference so the pdoc took me off of wellbutrin and left me on effexor saying tho there were better meds that he didn't want to change too much at once. He put me on topamax. 25mg first week and was to increase 25mg for 4weeks up to 100mg. Well I only made it two weeks up to 50mg. I was so severely depressed last night, I don't think I would have cared if I'd have been on a plane that was crashing. The lowest I've been in so long. I know it was the topamax causing it, it worsened every day. And as the day went on by nightfall it was horrible. SO today I left word with my doc and he called back and of course took me off of the topamax. (I was going to stop it regardless of what he said) I see him again in 2 weeks so he just said to leave it at that till I see him again. I feel so hopeless. Like I will NEVER feel happiness again. Does anyone have any ideas as to what could possibly help me?? I see here how everyone hates effexor, and I know how bad the withdrawl is, I had to stop it when I was pregnant in '01. Not sure if I'll ever stop taking it due to that. Maybe I need a higher dose? I don't think I need a mood stabilizer, esp. not one for mania! I need a GOOD AD. HELP! God bless you all and best of luck to everyone here. Thank you for listening and offering any experience you may have. :angel:
Quote from needmylifeback:
I've been clinically depressed for several years now. I tried several AD's with no luck, paxil, prozac, wellbutrin, celexa, zoloft, and finally effexor xr helped at the low dose of 75mg. Well about a year ago it starting to lose it's effectiveness. I saw someone and was diagnosed at the time with major depression recurrent without pyschotic features, needing a possible change in medicine and needing to rule out bipolar because it runs in my family. Well this month I went to a pdoc and he diagnosed me as bipolar II. Which I still really don't accept. Though I did have one mania episode in my life. It was 5 years ago and lasted about a year. First time it ever happened and it has never happened again. Most of the time I am depressed, sometimes severely, just existing. By this time I am up to 150mg of effexor xr and 300 of wellbutrin which I didn't see any difference so the pdoc took me off of wellbutrin and left me on effexor saying tho there were better meds that he didn't want to change too much at once. He put me on topamax. 25mg first week and was to increase 25mg for 4weeks up to 100mg. Well I only made it two weeks up to 50mg. I was so severely depressed last night, I don't think I would have cared if I'd have been on a plane that was crashing. The lowest I've been in so long. I know it was the topamax causing it, it worsened every day. And as the day went on by nightfall it was horrible. SO today I left word with my doc and he called back and of course took me off of the topamax. (I was going to stop it regardless of what he said) I see him again in 2 weeks so he just said to leave it at that till I see him again. I feel so hopeless. Like I will NEVER feel happiness again. Does anyone have any ideas as to what could possibly help me?? I see here how everyone hates effexor, and I know how bad the withdrawl is, I had to stop it when I was pregnant in '01. Not sure if I'll ever stop taking it due to that. Maybe I need a higher dose? I don't think I need a mood stabilizer, esp. not one for mania! I need a GOOD AD. HELP! God bless you all and best of luck to everyone here. Thank you for listening and offering any experience you may have. :angel:


That episode of mania may have been caused by one or all of the AD's you have taken; mania is a side effect of SSri's but the claim is that it only happens to people who may have latent bi-polar..... I think that's probably not true, since we all have different reactions to drugs, chemicals, allergens, etc. I think it's just that some people just have adverse reactions to SSRi's just like anything else!

The "unmasking" of bi-polar when one is on an AD cracks me up. If the drug causes mania, it causes mania, and some people have different sensitivities to drugs, so that doesn't mean the person is manic-depressive or bi-polar.

Do you ever hear of a drug "unmasking" diabetes or cancer? Ridiculous.

There is one person I talk to on this board who was told that very thing, but funny how when she tapered down her AD that the mania completely disappeared!! :eek:

On the subject of depression, if you want natural relief, eat alot of dairy, eggs and meat, in other words high quality protein because that's what breaks down into amino acids and those make serotonin and other neuros. It does take some starch(complex carbs) to complete the process, or even something simple like orange juice. B- vitamins are also important to the process.

There were also studies that fish oil greatly relieved depression. Omega 3's are brain-healing.