I am on 300mg Wellbutrin XR and this has been the best antidepressant that I have tried. I have been thru atleast a dozen different kinds. I was on Paxil twice. The first time I gained 20 lbs within just a few months but thought it was because I took it in combination with other antidepressants. A few months after I stopped taking the Paxil I lost the weight. However, when I tried it again by itself a year later I gained 20 lbs again. I am only 5ft and typically weigh 107lbs so needless to say my body frame was not meant to hold that much weight and I now have stretch marks from top of my body to the bottom. But that's just me. Anyways, back to the Wellbutrin. Every antidepressant that I've ever been on took a few weeks for my body to adjust(side-effects). I actually think it helps me sleep better. With the depression and other antidepressants that I've had I slept all the time. But now I actually wake up well rested after 8 hours rather than always tired. I will say that I do have allergies and take Zyrtec and it doesn't interact with the wellbutrin. However, I can't take most over the counter antihistamines because with the Wellbutrin I get the jitters. Do talk to your pharmacist though, because there are a select few OTC antihistamines that works fine with the Wellbutrin. Usually Wellbutrin will only cause seizures if you either have/had an eating disorder or are already suseptable to seizures. Sorry ,bout the book but hopefully this will help you feel better about your concerns on Wellbutrin XR. Hope all goes well for you.