I just started taking 30mg of Cymbalta last Tuesday. I did have some nausea and the runs. Tomorrow I'm supposed to start taking 60 mg. I still don't feel well, but my depression is lessening a little. I know it takes some time to adjust to anti depressants and usually takes a couple weeks for it to really start working. I'm going to try and stick it out because I cannot stand feeling bad and depressed all of the time. I was on Paxil before that for anxiety and it just did not work for the depression. I've had alot of sad things happen since June and have had a heavy heart for too long. I hope you find something that you can tolerate.