Discussions that mention phenytoin

Alzheimer's Disease & Dementia board

OK ~~ Armed with THAT info (thanks fourt9rkim) it states here:

Paroxetine (Aropax, Oxetine, Paxtine) is in the antidepressent range and is in the Selective Serotonin reuptake inhibitors (SSRI's), and if prescribed for depression there is an initial dose of 20mg orally daily (increase by 10mg per day at weekly intervels or to a max of 50mg if necessary).

Adverse effects/Interactions/Cautions:
May alter plasma concentrations of phenytoin, therefre pt should be closely monitored for signs of toxicity or seizure activity
Contraindicated with thioridazine
Administed as a single morning dose WITH fod
Tablets should be swallowed whole, not chewed

No mention of half-life however, as an SSRI drug, it can cause:

Palpitations, tachycardia, hypotension, dizzines, tremor, headache, twitching amnesia, apathy, anxiety, nervousness,aggravated depression, nausea, anorexia, diarrhoea, altered taste, dry mouth, increased appetite, increased weight, increased saliva, fatigue, hot flushes, increased sweating, yawning, chills, insomnia, rash and disturbances to vision !

She should not be drinking any alcohol, and carefully monitored if she's on any anticoagulant therapy and caution exercises if she's on any herbal remedies that contain St. Johns Wort. If she is diabetic, blood glucose concentrations should be closely monitored.

If you want her off it, the dosage should be tapered off gradually to prevent withdrawals, and discontinued if she shows any signsof mania or hypomania. Treatment should continue for at least 6-12 months FTER depressive symptoms have abated. Caution if used in thoe with pre-existing slow heart rate, history of bleeding disorders or taking drugs affecting platelet function with epilepsy, history of convulsive disordes or glaucoma.


This might sound double dutch, but there is much more to legal drugs than just prescribing.

Example: My doctor wanted to put me on an iron supplement to combat my chronic anaemia (lucky me), but his COMPUTER told him that it was incompatable with my thyroid medication. He shrugged and said "Take it later then". My research showed me about 12 hours need to pass between the two, and ideally another option should be found.

I'm seeing him Saturday week to educate him :-)