Discussions that mention pravachol

High Cholesterol board


My new cardiologist stopped the Pravachol and started me on Crestor. Most of the leg pain has dissipated. However, the past few days I have had the sensation of shortness of breath. I’m not gasping for air, I just have the occasional sensation of not getting enough air.
Has anyone experienced anything similar while taking Crestor?
Quote from donsabi:
My new cardiologist stopped the Pravachol and started me on Crestor. Most of the leg pain has dissipated. However, the past few days I have had the sensation of shortness of breath. I’m not gasping for air, I just have the occasional sensation of not getting enough air.
Has anyone experienced anything similar while taking Crestor?


I went from Pravachol to Crestor over a month ago..no problems. What dosage are you taking? 5 mg of Crestor is at least equivalent to 40 mg of Pravachol! I know most Drs start with 10 mg, but I use 5 mg 4X a week and 10 Mg 3X. So...you might want to try cutting back the dosage and see what happens. You do need to tell your Dr about the shortness of breath.
I've been taking 5mg of Crestor for the past week and now the leg pain is back. As a matter of fact, it is actually worse than when I was taking Pravachol which is why I switched in the first place. I am stopping Crestor today and see if the leg pain subsides.
Quote from donsabi:
I've been taking 5mg of Crestor for the past week and now the leg pain is back. As a matter of fact, it is actually worse than when I was taking Pravachol which is why I switched in the first place. I am stopping Crestor today and see if the leg pain subsides.


Sorry to hear that...let us know if the pain subsides.
I guess everyone reacts differently. I had recurrent mild thigh pain with both 10 mg Lipitor and 40 mg Pravachol, but none whatsoever with Crestor. I also had the unusual side effect of somewhat worsened blood sugar control with Lipitor, but not with either of the other statins. I was having some insomnia (waking too early) the first month I was on Crestor, but I'm not so sure there was any causal link there.

Given all of this, plus the great lipids numbers (and no indication of liver enzyme elevations), I'm a big fan of Crestor -- at least so far. I sure hope the ambulance chasers and sky-is-falling "consumer protection" groups that are attempting to have the FDA ban Crestor are unsuccessful.
I stopped Crestor four days ago and each day I have been feeling better and better. I had some leg pain from Lipitor and Pravachol but Crestor was the worst. I felt like I had a tooth ache in my legs. Nothing relieved the pain. I also had cramps and spasms. I am not bashing these meds just posting my symptoms. I am sure there are many people who will swear by these meds. They are the fortunate ones.
I do take Niaspan and supplement with fish oil and apple pectin.
Can anyone offer any other options?
I've heard about some people having excellent results with the supplement policosanol. The supplement pantethine (NOT pantothenic acid) also helps some at pretty high doses, and lowers triglycerides, too. Neither supplement generally has side effects. If you are taking Niaspan in conjuction with meds, be sure to tell your doctor. Also if you are diabetic or at risk (overweight, over 40, out-of-shape, and/or family history), be sure to have your glucose tested once or twice a year, since Niaspan can sometimes raise blood sugar.

As for statins, differences in peoples' reactions may be due in part to the fact these meds are all fundamentally different to some extent. Pravachol is natural and water-soluble; Zocor is natural and fat-soluble; Lipitor is synthetic and fat-soluble; and Crestor is synthetic and water-soluble.
Quote from RickRick:
I guess everyone reacts differently. I had recurrent mild thigh pain with both 10 mg Lipitor and 40 mg Pravachol, but none whatsoever with Crestor. I also had the unusual side effect of somewhat worsened blood sugar control with Lipitor, but not with either of the other statins. I was having some insomnia (waking too early) the first month I was on Crestor, but I'm not so sure there was any causal link there.

Given all of this, plus the great lipids numbers (and no indication of liver enzyme elevations), I'm a big fan of Crestor -- at least so far. I sure hope the ambulance chasers and sky-is-falling "consumer protection" groups that are attempting to have the FDA ban Crestor are unsuccessful.


Got this from Diabetes forum:

I stopped taking Lipitor since I seemed to be having quite a few side
effects from it, though it was hard to say what was causing what,
since I was ill with thyoid troubles at the time too.

Since then I've been on "Crestor" (Rosuvastatin) which I've been on
for about two years (as part of a drug trial) now without any trouble
at all. Crestor has an amazingly low side effect profile and many who
have had trouble with older statins are doing well on Crestor.

It has lowered my cholesterol to normal for the first time ever. I
have familial hypercholesterolaemia and my "normal" cholesterol levels
are near to twice normal _maximums_. Crestor has halved my bad
cholesterol readings.
Thanks for the interesting post, Rahod.

I suppose you've seen today's news reports about the new noise Sidney Wolfe of Public Citizen is making about Crestor, via a lengthy letter to the Lancet calling for the FDA to ban it. The FDA, which unanimously approved Crestor, is fortunately standing firm against these alarmist tactics while continuing to monitor things. That's a reasonable stance, unlike Wolfe's. It appears that he is beginning to react like a child that just can't get his way, but on a grander scale. I wouldn't be surprised if the next thing we hear is that he has vowed to go on a starvation diet until Crestor is banned.

As you know, and as posts to this forum demonstrate, while most people tolerate the statins very well, others can have adverse effects ranging from mild to pretty nasty. I have an aunt whose cholesterol is very high, but her body just can't tolerate any of the statins. But as you may know, in 12-week Crestor pre-marketing studies, the proportion of people who dropped out due to side effects was actually greater in the placebo group than among those who were actually taking Crestor.

BTW, some of the TV reports I've seen on Wolfe's latest rants have been alarmingly inaccurate. On one station, they stated that Crestor is the only currently-marketed statin that has ever caused rhabdo! Sheesh, don't they bother to check any facts? Even Wolfe would't claim something that preposterous (or would he...?). I note that Public Citizen also states on their site that no one should take Lipitor, the #1 drug in the world, although they're not calling for a ban. Pravachol and Zocor somehow manage to score their "seal of approval".
The important point is that the "dangers" of Crestor discussed in the article are NOT unique to this drug. What happened to Otis Elliott is unfortunate (although it's nice that he's recovering better than expected -- his was one of the worst of the rare rhabdo cases). but the same thing has happened to people taking Lipitor and Pravachol as well. There have been no deaths due to Crestor. It's a drug-class rare side effect. Relative to cholesterol-lowering impact, Crestor has shown about the same incidence of rhabdo (severe, life-threatening muscle deterioration that can destroy the kidneys) as the other currently-marketed statins. And again that happens very rarely for Crestor (and Lipitor et al), especially at low doses. It is not anywhere near the rate that was seen for Baycol, which was taken off the market a few years ago. (Interestingly, it was a news report that I Googled up from Elliott's hometown TV station's website that made the absolutely ridiculous claim that no other currently marketed statins have ever caused the malady he suffered.)

Now, Crestor has indeed shown a unique-among-statins, but rare, incidence of non-rhabdo kidney dysfunction, but this was only at the high doses Rahod referred to. There have been more problems in Europe than the US because doctors there have paid less attention to Crestor's instructions to always start with a low dose. (There has been some re-labeling there as a result.) And BTW, lots of approved drugs, as well as over-the-counter herbs and supplements, can rarely cause kidney failure, hepatitis, pancreatitis, and more.

Unfortunately, the press and TV get more mileage out of playing up the sensationalistic angle and paying scant attention to facts, good science and statistics. (I just love the reports that say, "40 people suffered such-and-such" without telling you the vital fact of OUT OF HOW MANY??) And, quite understandably, people who have had problems with a drug -- *any* drug -- are more likely to post about their experiences than those who had good experiences.

Granted, the Lancet feels Crestor was rushed to market with insufficient testing, but it was actually tested on far more people than any statin that preceded it.

People (including myself) are good at being skeptical of drug companies' motives. Like many others, Crestor maker AstraZeneca has pulled its share of stunts (misleading studies, attempts to suppress generics, etc.). But please, people, realize that you must have equal skepticism of the exaggerated and often irresponsiible "danger" claims you see in the media, on the internet (those malpractice lawyers salivate over this stuff), and from "consumer protection" groups like Ralph Nader/Sidney Wolfe's Public Citizen. It would be interesting to see the extent to which reactions changed if the news reports pointed out that Public Citizen also lists Lipitor as a "bad drug" that nobody should take. (As I said before, they say that Zocor and Pravachol are "good drugs.")

If you look at the link below, be sure to look at the Q&A, too. Obviously there can be some bias because it is on the manufacturer's website, but they do make some good points.

Rick

[url]http://www.crestor.com/c/message/[/url]