Discussions that mention pravachol

High Cholesterol board


I've only been on Lipitor 40mg for a few weeks, but have no side affects. I have F.C.H., and had previously been on Pravachol 80mg...in fact, I'm pretty sure after a trial period I'll be going to Lipitor 80mg along with the Zetia I take.

So far, nothing bad at all to report on Lipitor, but I do have a similar experience to report:

Several years ago I was put on Pravachol 40mg, and had some of the symptoms you had. Weakness, low energy. I complained to the doc, and he backed me off to 20mg.

On 20mg I had no such symptoms at all, however over time it was clear that 20 wasn't cutting it. I asked the doctor to up me back to 40mg, and lo and behold...no side affects! It seems that I had adapted to the medicine and could tolerate larger doses. Later I went to 80mg also without any noticeable affects.

You may want to consider backing off your dose to something small that you can tolerate, with the idea of building it to what you actually need.

As a side note, this is my first post since joining this board, and I'm going to start a separate thread for FH...Familial Hypercholesterolemia, an inherited disorder where your cholesterol levels won't adjust to any diet, and even resists drugs to some extent.

good luck,

mark
Mark,

Just keep in mind the fact that Lipitor is 4 times as powerful as Pravachol. So, 80mg Pravachol is equivalent to 20mg Lipitor. I certainly hope you never need to take an 80mg dose of Lipitor.
Quote from ARIZONA73:
Mark,

Just keep in mind the fact that Lipitor is 4 times as powerful as Pravachol. So, 80mg Pravachol is equivalent to 20mg Lipitor. I certainly hope you never need to take an 80mg dose of Lipitor.


What I recall of Lipitor literature is that 40mg produced an average 57% reduction in LDL vs 39% for 40mg Pravachol. That would make it slightly more than 2x of Pravachol.

Furthermore, if each doubling of a statin dose tends to produce an additional 10% reduction in LDL levels, then I am hoping that 40mg of Lipitor will produce a slightly better result than 80mg of Pravachol, and that it will have a marginally positive effect on HDL as well.

If those numbers are anywhere near accurate, then there is NO WAY that anything but a max dose of Lipitor will get me down into the 70's of LDL that I'm looking for. FH can be extremely resistant to both diet changes and drugs.

My last reading on 80mg of Pravachol and zetia was:

178 total, 113 LDL, 34 HDL, 157 Trigs

I got put onto only 40 of Lipitor because I'd moved to a different state and made the mistake of going to a nurse practitioner instead of a doctor. Her approach was that of a clerk's not a medical practitioner, and I've dropped her in favor of a doctor.

Crestor has possibilities, but given its record I won't press for that until I see what Lipitor can do.

mark
Quote from mhtyler:
...then I am hoping that 40mg of Lipitor will produce a slightly better result than 80mg of Pravachol, and that it will have a marginally positive effect on HDL as well.

If those numbers are anywhere near accurate, then there is NO WAY that anything but a max dose of Lipitor will get me down into the 70's of LDL that I'm looking for. FH can be extremely resistant to both diet changes and drugs.

Crestor has possibilities, but given its record I won't press for that until I see what Lipitor can do.

mark



I would take 10 mg Lipitor and 10 mg Zetia..PROVEN to have the LDL lowering of 80 mg Lipitior alone. Certainly better than 40 mg Lipitor alone and easier on your liver! Don't rule out Crestor..I take it with no problems (just added 1/2 dose of Zetia as well and will soon post my results). Crestor 10 mg and Zetia should get you to well below 70mg LDL level. That's what I'm shooting for now.
Quote from ARIZONA73:
Mark,

I hope that your doctor at least advised you to take Coenzyme Q10, especially since you are on such a high dose of Lipitor. These drugs have a tendency to deplete CoQ10 levels, and when that happens you are much more likely to run into problems. But I'll bet he didn't. Am I right?


No he didn't, and I remember reading something about that, but can't recall. I'll look into it. I didn't mention I guess, but I do take Zetia already as well, and did so when I was taking 80mg of Pravachol.

My last reading at that dosage was:
182total 93ldl 39hdl 252trig

Nothing to write home about.

I don't know if any of you folks here have FCH as I do, but so far the drugs I've been on have not produced miracles. I have on a low fat diet for sometime, although I've been known to get off of it after seeing the awful results of my cholesterol tests. I've been under treatment for three years and I've never been able to get my LDL below 93, and the lowest my Total to HDL ratio has ever been is 4.7. I hope you guys are right and Lipitor behaves in some magic way that Pravachol didn't.

Recently though I've significantly lowered my intake of sugar as I finally figured out that I have metabolic syndrome as well. That may have been impeding my HDL levels. We'll see.

mark
My dr wants me to start pravachol. I am afraid bcuz of the side effects i had with the lipitor. First dosage was 40mgs, then a yr later 20 mgs and finally, my endo put me on 10mgs. I didn't have too many side effects, but i just stopped taking it when i ended up in the ER. I've tried zetia.
Is pravachol a statin?(i think i've asked this b4) Will it have the same side effects as lipitor or zetia. MY cholesterol problem is from my bp meds, but im diseparate to lower my cholesterol by Oct. 15th when i have to go for blood work.
Pravachol is a statin, and they all do the same thing, they inhibit the production of vldl in the liver so that it impedes the production of LDL. Some are stronger than others. Pravachol is a bit weaker, and Lipitor is one of the stronger ones. Crestor is considered a superstatin...more powerful than Lipitor, but at 80mg doses people had problems.

I initially had side effects on pravachol at 40, then backed off to 20 and adjusted, and finally was on 80mg without apparent side effects.

I'm far from sure of my facts, but it does seem that it is possible to adapt and adjust to a statin over time.

mark