Discussions that mention pravachol

High Cholesterol board


From the Public Citizen Letter:

"Crestor: There have been 29 reported cases of acute renal failure or renal insufficiency (18 cases of failure and 11 cases of renal insufficiency) out of 4.5 million prescriptions filled between the first time the drug was marketed in the U.S. – September 2003 – and the end of August 2004. This is a rate of 6.4 reports of acute renal failure or renal insufficiency per million prescriptions filled.

All other statins (Lipitor, Zocor, Lescol, Pravachol and Me****r, including other versions of lovastatin): There have been 27 cases of acute renal failure or renal insufficiency reported from January 1, 2001, through September 30, 2003, out of 316 million prescriptions filled for these drugs during this interval. This is a rate of 0.085 cases reported per million prescriptions filled. The highest rate for any of these other statins was for Zocor, which had a rate of 0.26 cases per million prescriptions filled.

Thus, the rate of reports of acute renal failure or renal insufficiency for Crestor is 6.4/.085, or 75 times higher than that of all of the other statins combined. In comparison to Zocor, the rate of reports of acute renal failure or renal insufficiency for Crestor is 6.4/.26, or 25 times higher than that of Zocor."

>>>>The basis of Crestor was only 4.5 million, while the collective basis of the others was 316 million..or 70 TIMES the size (in this case # of Rx filled)! They didn't state the Zocor alone basis, but it's definitely MUCH larger than the Crestor's 4.5 million..probably 100 million plus. The point here, is that STATISTICALLY you need comparable population size (ie, # of Rx filled), since the LARGER the size, the more things tend to smooth out. This is a fairly RARE phenomenon and they made the mistake of EXTRAPOLATING results in a relatively SMALL population in order to compare it to results in a vastly larger one. Example: Would you compare the results of a study using TEN SUBJECTS to one that used 700?