I have been on Enbrel since Sept. 12, 2006. I find a big difference. Alot less pain, stiffness and swelling. My doctor decided to cut all my other medications in half. That was a month ago and I am still doing very well. I am tappering off of Prednisone and this time it is alot easier. It has made me alot happier. My friends and family noticed a big difference in me before I did in myself. I can do more then I use to. I am almost back to my old self. It has worked for me.