I was on Methotrexate and Prednisone. I had all of the symptoms you described, hair falling out, round face, weight gain, etc. My skin was so thin, I would literally scratch it and it would bleed. The Methotrexate made me tired about 3 days out of the week. I started the Humira shots last June and have been able to get off all of my other meds. All of my side effects are gone. People think that I have lost a ton of weight. I have lost a little, but it just looks like I have lost more because all of the puffiness is gone. My skin is fine now, hair does'nt fall out, and I feel great.
Thank god for the Humira. I hate taking medicine, but I know I had to if I wanted any kind of quality of life. I have RA and up until I started the Humira I was miserable and thought that I just had to live with it and adjust my life. Then I found a tremendous doctor that changed everything.
Hopefully the Enbrel will enable you to get off of some of your meds. Best of luck with it.