I was taking 2 benadryl every three to four hours. Prednisone has not helped. I did determine what was causing my problem. I am allergic to my 12 year old cat. Since I will not be finding my cat another home, I guess I will deal with it. I am still taking benadryl three times a day. Three in the morning and before bed and two at noon. My doctor is agreeable with this. It doesn't get rid of the hives, but merely makes them bearable. I still itch, but not uncontrollably. After two visits to the hospital ER, I was put on Methylprednisolone dose pack. It worked for the duration of the dosage, but not after. I have tried topical steroid creams, no help. Benadryl is my best bet so far.