Today is monday...thursday afternoon my girlfriend noticed her hands were swollen. by friday morning she had broken out in a mild case of hives. I started her on benedryl, which did nothing. By sunday morning, her feet were so swollen she could not walk, and her chest had tightened up causing her to have trouble breathing. I took her to the ER where the gave her an IV of benadryl, pepcid, and some steroid (not prednisone) after a few hours there, the hives and calmed, and we left with a prescription for prednisone. we got home, and she took her first dose. one dose every day for 5 days. she was doing ok for the rest of the day, then last night her hives started coming back. by 3 am, the were so bad that she couldnt sleep, she was in loads of pain and extremely itchy. this morning they are probably twice as bad as they have been since the begnning, and shes miserable. benedryl isnt doing anything, and it seems like the prednisone makes them subside a little, but they just come back worse after it works its way out of her system. We have no idea what caused this to begin with, she never at anything out of the ordinary, and she doesnt have any food allergies. she hasnt slept, and i want ot give her either tylenol pm, or ambien so she can try to sleep through the worst of the itching. The info sheet i was given for the prednisone says you should not take sleep inducing meds, but i have read some places it is ok to. can anyone help me at all???