Hello. I too am on Mtx. I have something like Rhum. authritis. Mtx started working for me in about three weeks. I also take ibprofin everyday for the aches and pains. I guess that is common. I am also on prednisone 15 mgs a day. I was told that eventually i will only need the mtx. Its been four months now and i still need all the other meds too ????