Discussions that mention prednisone

Arthritis board


Are you currently taking Sulfasalazine..and thinking of switching to Plaquenil? Plaquenil is actually considered one of the safer drugs and it can be taken with many other drugs without any reactions. The only thing is that it can take up to several months to feel any results, it's definitely not a quick fix. When I started it, my Rheum put me on both Prednisone and plaquenil..I took and tapered off the prednisone over about 8 months & in the mean time i was taking 400 mg per day of Plaquenil...so it had lots of time to build up in my system.

There are many other anti-inflammatories, though I have tried many without any relief. I have tried Mobic, Relafen, Bextra, Celebrex, Feldene, Ansaid, Prednisone, Medrol Dose Packs, and others that I cannot remember. But I am pretty sure there are other DMARDS like methotrexate for PA and RA. Hopefully someone else who has more knowledge with those diseases/treatments will reply...
Thank you so much.

Did you have any side effects form the Prednisone? My rheum does not want to give me Prednisone although I have asked. First off - she wants me on Methatrexate. I said no. So she offered me two other choices, Plaquenil and sulfasalazine. So it is a litrle frsutrating. I know rednisone works wonderfullly in theshort term. I'm not looking for long term, so maybe I can suggest the combo of Plaquenil and Pred until the Plaquenil sets in?

I have only been taking flurbiprofen. It takes away the edge. I still have some stiffness and slight pain if I over-exert myself. So, I guess you could say I'm stressing over what is the best coarse of medciation for my Spondylosis and PA.

Thanks for posting your reply. It is helpful.
If you're looking for the safest with the least amt of side effect, I'd go with Plaquenil. Not that it doesn't have it's share of problems but it does seem to be much better tolerated than most other autoimmune medications. I was on it for years with no discernible side effects (other than tummy ache if I forgot to take it with food) and it worked well for a mild DMARD. I did need to go to the eye doctor once a year for an eye check but that was it. I'm allergic to sulfa drugs, sulfa allergy doesn't go away, so if that's what you have you'll have to stay off sulfasalazine and Celebrex as well.

A short course of prednisone can ease you into Plaquenil, which may take several weeks to work. I have lots of side effects with pred. You couldn't get me to take prednisone if it were water and my head was on fire;) but some people have little or no side effects, esp short term. It's up to you.

If you're looking for the most effective, go with Enbrel. It's approved for both RA and PA. Works wonders, unfortunately it's a shot (you give yourself, bleh!) and while I was on it I got sick alot from the immune suppression - but it worked really well. I only stopped because I developed a tolerance to it and I'll have to wait years before I can try it again.
I personally did not have many side effects on the prednisone. The first time I took it, when I was on it for 8 months, I did get moon face, but I also actually lost some weight; It worked so well for me and I was able to exercise again and walk around, etc... Oh, I also bruised more easily, but other than that, I did not notice any other effects. It just was my miracle med! If I could take it all the time and not get any long-term effects, I would.

Also, it certainly wouldn't hurt to ask about the pred/plaquenil combo..