I have had depression for many years, but several years ago I went on Paxil and Serzone as a combination and felt wonderful! I remember feeling more at peace and happy than ever in my life. I was sleeping well, which has been a big issue for me. I went off the Serzone last fall since it had been pulled by the FDA for liver problems. I also went off Paxil shortly afterward. (The withdrawal from Paxil was tough, to say the least!) I was hoping I could go without meds, but I bottomed out. Since Christmas I've been trying lots of different meds, including Buspar, Effexor, Celexa, Prozac, and now Cymbalta. Insomnia is a huge problem for me on all these meds. Has anyone had issues with insomnia as a side effect of ad's and found something that didn't cause the insomnia? I think there was something about the Serzone that really worked for me, but I can't risk the possible liver problem. Thanks for any help!