What about Pamprin? I am looking for something to help with cramps and fatigue. I also get in very depressive periods during this time - this time it coincided with a couple of bad events in my life, and I got to the point where I was having thoughts of suicide. I am slowly starting to get out of it, but that was kind of a scary time. I have said before that I do sometimes skip periods, and my cycle is pretty irregular. I think that may play into the moodswings and such, making them worse. I'm mainly looking for something that will help with the fatigue, headaches, cramps, and irritability. I know a cure for the moodswings is asking too much, but maybe getting rid of the other symptoms will alleviate some of it. I have also heard of people taking Prozac or Serafem two weeks out of the month, but I hate to get into prescription drugs... Is the OTC stuff helpful at all?