Discussions that mention prozac

Addiction & Recovery board


I think somehow our posts crossed each other. I believe the difference between tricylics and SSRI's is the molecular makeup of the drugs. SSRI's are a newwr class of antidepressants and now there is an even NEWER class of antidepressants that I know nothing about. ( I think that Cymbalta is one that is in the newest class).

The tricylics and SSRI's block the receptors from sucking up too much seratonin, a chemical in your brain that is the "feel good" chemical. I think the newest class of antidepressants actually work on both serotonin and dorphomine(sp) chemical (another "feel good" chemical naturally produced by the brain.

Do some research on tricylic antidepressants (which is what you are taking). You know, it's funny.... a lot of research will say they are not addictive. Research said the same about SSRI's, bit I KNOW it was mentally painful when I tried to just stop them cold and I couldn't do it.

Well, I shouldn't be so quick to jump and say that. Actually, my very first depression came on when we lost my father-in-law, both my parents and my uncle were diagnosed with cancer and all happened within a month. I tried to care for them, work, run my house and go to school and eventually fell apart. In retrospect, I DID come off prozac (an SSRI) cold turkey, but had only been on it a few months. Geeze, I had forgotten that.

The second depression I was on was a very, very severe clinical depression. After dealing with my parents and uncle, (Dad and uncle died on same day and Mom had to be taken for chemo between funerals), I myself was diagnosed with a very rare cancer and had many radical surgeries, chemo, radiation and got broadsided by an eighteen wheeler during my treatment. To boot, I was thrown into overnight menopause during the radiation which burned out my ovary (only had one at that point in time). When I tell you the depression was deep, even the docs did not think I was gonna make it.

I was treated atbthat time with all kinds of drugs... tricylics included. Eventually, I was able to fight my way back and ended up on Prozac as a maintainance antidepressant. Was on that a long time when it "pooped" out and made the switch to Lexapro.

Even the switch within the same family of antidepressant was tough for about 2-3 weeks with my depressive symptoms reappearing hard before they let up.

Sometimes I think about coming off of them somewhere down the road. I know that an element of the chemo I was on did screw up my receptors. But a lot of other stuff was going on, too. Maybe when I have detoxed from these pain meds and have regained my strength again, I will give more thought to coming off.

Sharon, why were you put on them? I mean do you understand the root of your depression? Why do you want to come off? Just sick of taking them? Just being curious. These thoughts cross my mind also.

I have yet to come to a decision myself. I know it is a hard one to make.

Please do do research on tricylics. As I said, I researched dithapin and was surprised by the lack of material on the web. But as it is a tricylic, do your research on that.

Come back and share with us all.

Hi Sharon – I've been on Dothiepin (also known as Dosulepin, or Prothiaden in the US) on and off for about 10 years now, so maybe can help you from direct experience – though bear in mind people can differ.

Dothiepin is a very old tricyclic antidepressant. Unlike modern SSRI’s (like Prozac) which only really increase the level of one of the chemicals in your brain (serotonin), it has more of a shotgun approach, and also increase the levels of others, eg dopamine. For some people that works better.

Peoples’ precise needs from an antidepressant differ; some people are anxious kind of depressives (me), and others are the half-dead, sleepy types. It depends on your individual brain chemistry. All drugs have different side-effects; one of Dothiepin’s is that it tends to calm you, and help you sleep. I suffer from insomnia, which is why it was specifically prescribed for me. If you have a tendency towards anxiety or insomnia, that’s probably why you were put on it.

Regarding coming off it, I’d need to know what dose you were on. It should be either 75mg or 150mg. If it's 150mg, it will take longer. It affects me quite powerfully, so even though I’m a 17-stone man, I only take 75mg.

Someone mentioned Doxepin – that’s not the same thing, but is related. I can't take it, because even one capsule of it makes me sleep for about 15 hours, and I can't function the next day!

To come off Dothiepin suddenly is absolutely a bad idea. Again, people are different, but on the rare occasions when I forgot to take a table before going to bed, the next day would be one I didn't forget in a hurry. But coming off it slowly, I find no problem. Personally, I reduce the dose by 25mg a week until it's all gone, and that’s worked fine for me.

The only reason I keep going back onto it is because I have a drinking problem, and when I drink I get chronic insomnia and anxiety. Fortunately the gaps between binges are becoming longer and longer as I tolerate it less and less... hopefully some day I’ll be able to pack it in, and come off the Dothiepin for good. I really don’t need them if I don’t drink...

Good luck!

PS somebody mentioned blood pressure – Dothiepin can actually INCREASE blood pressure in some people, so coming off it might even reduce it. You’d need to monitor it if you think it's going to be a problem.