Thanks for your response. I talked to my doctor yesterday, and he said to try it more slowly. So I am taking 25 mgs instead of 50 for a week or so, and then see if I can increase it to 50 again. I certainly feel more anxious than depressed, like you. I sure hope it settles down real soon. I feel like I am wired, but I think part of that is because I didn't taper from prozac 30 mgs, but just went to 50 mgs of zoloft. It took me like ten years to increase prozac to 20 mgs! Also, I'm not sure even looking at all the stuff on the internet is a good thing, as you hear good stories to horror stories, did I make the right decision to change meds, will this just be worse, etc. But when you find someone, like yourself, who seems to be doing well, that does give me some hope. It's this interminable waiting for a good effect that is the worst. Please keep in touch. I need to hear positive things. Did you have bad side effects in the beginning? Did you start right at 100 mgs? If you had side effects, what were they, and did they eventually pass? Thanks.