Spin, please don't misunderstand my original post. I was not suggesting that Shelly just jump in with both feet and ask for another medication or higher doses or anything of the sort. I was simply suggesting that she may be one of those few people who are like I am; those who ARE helped by more than one medication. I found out that I NEED two different antidepressants during periods of switching over from one med to the other. My psychiatrist over-lapped the switch from Serzone to Wellbutrin and I felt really good. After I stopped the Serzone I didn't feel really good. I didn't want to go back on Serzone (this was long before they pulled it) so we tried amitryptyline. I didn't like that either. My family doctor tried Remeron and I didn't like that. Finally, after thinking about it a great deal I went and talked to my doctor about Effexor. I'm on a fairly low dose of it and I have no plans to increase it if it can be avoided. I know about all the warnings about withdrawal, but I doubt that I'll ever have to worry about that because I'm going to be on meds for the rest of my life.