I just got a new doctor. He's way better than the last one I saw. The new doc changed my meds to Effexor, Remeron and lorazapam. I've been taking 150 mg of Effexor for over a month, but have not noticed any changes...Only side effects. Before then, I was on Prozac, but it stopped what little good it did after 2 years. I've been tried on so many different meds...What if none of them help? Can that happen?