I suffer from migranes and was put on an antidepressant and immediately my RLS went into over drive. I asked my neurologist about it and he said there was no relation. He put me on Requip and it has helped. When I returned to him 6 months later I told him that I have slowly gotten of of the antidepressant because of the relation between it and RLS he denied it and got a little huffy. I know my body. And I am considering finding a new doctor. I hope that this information helps someone.